ArticleRSC advances2026
Green RP-HPLC method for the simultaneous determination of octenidine and phenoxyethanol in antiseptic formulations: integration of a lean six sigma approach.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
A green and efficiency-oriented Reversed Phase High Performance Liquid Chromatography (RP-HPLC) method was developed for the simultaneous determination of octenidine dihydrochloride and phenoxyethanol in antiseptic formulations. Unlike previously published studies, the present work offers a fully detailed, optimized, and rigorously validated isocratic method providing simultaneous quantification with a short run time of approximately 8 minutes. Excellent resolution was achieved using an Agilent Zorbax cyanopropyl column (250 × 4.6 mm, 5.0 µm) with a mobile phase of acetonitrile and water (each containing 0.1% trifluoroacetic acid) at 60 : 40 (v/v), a flow rate of 1 mL min
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