ArticleDrug design, development and therapy2026
Regulation of Periodontal Ligament Autophagy by Super-Activated Platelet Lysate in a Rat Maxillary Expansion Model.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the regulatory effect of Super-Activated Platelet Lysate (sPL) on autophagy of periodontal ligament stem cells (PDLSCs) during rat maxillary expansion, with implications for optimizing orthodontic treatment outcomes. Methods: Fifty-four male Sprague-Dawley rats were randomized into control, maxillary expansion model, and sPL-treated groups. After expansion model establishment, arch width was monitored, and maxillary samples were collected on days 3, 7, and 14 post-expansion. Histological staining (H&E, TRAP) and immunological assays (IHC/IF) were performed to evaluate periodontal tissue morphology, osteoclast activity, and autophagy-related marker (LC3B, LAMP2, mTOR) expression. Results: All rats adapted well after expander installation with no mortality. Arch width increased significantly over time. H&E staining showed narrowed periodontal space, disorganized fibers, and localized bone resorption in the model group on days 3 and 7, with stabilization by day 14. The sPL group exhibited improved tissue morphology by day 7 and stabilization by day 14, though with slightly increased osteoclast activity. TRAP staining revealed elevated osteoclast numbers in the model group on days 3 and 7, decreasing by day 14, whereas the sPL group had fewer osteoclasts initially but more by day 14 (all Conclusion: sPL can modulate PDLSCs autophagy during maxillary expansion, a novel regulatory mechanism that may mitigate alveolar bone complications and shorten orthodontic treatment duration. This finding highlights sPL's potential as a therapeutic agent in orthodontic practice.
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