Evidence map›Paper›PMID 41858839›Full record

ArticleContemporary clinical trials communications2026

(Cost-)Effectiveness of personalised multimodal physiotherapy compared to surgery in patients with painful cervical radiculopathy. Protocol for a randomised non-inferiority trial (The MOVE-IT study).

Florine E Marinelli, Ivo J Lutke Schipholt, Sebastiaan Klein Heerenbrink, Michel W Coppieters, Johanna M van Dongen, Raymond W J G Ostelo, Sjoerd C Kielstra, Carmen L A Vleggeert-Lankamp, Mark P Arts, Bastiaan Ter Meulen and 7 more

Abstract read
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In one paragraph

Article in Contemporary clinical trials communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Florine E MarinelliDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
Ivo J Lutke SchipholtDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
Sebastiaan Klein HeerenbrinkDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
Michel W CoppietersDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
Johanna M van DongenDepartment of Health Sciences, Amsterdam Movement Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.
Raymond W J G OsteloDepartment of Health Sciences, Amsterdam Movement Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.
Sjoerd C KielstraDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
Carmen L A Vleggeert-LankampDepartment of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
Mark P ArtsDepartment of neurosurgery, Haaglanden Medisch Centrum, Lijnbaan 32, 2512 VA, The Hague, the Netherlands.
Bastiaan Ter MeulenDepartment of Neurology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, the Netherlands.
Hans J L W BosboomDepartment of Neurology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, the Netherlands.
Femke van NassauDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.
Pieter CoenenDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.
Servan RookerDepartment of Neurosurgery and Orthopaedics, ViaSana clinic, Hoogveldseweg 1, Mill, 5451 AA, the Netherlands.
Marije L S Sleijser-KoehorstDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.
MOVE-IT Research Group
Gwendolyne G M Scholten-PeetersDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences - Program Musculoskeletal Health, van der Boechorststraat 9, 1081 BT, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Painful cervical radiculopathy can lead to substantial and long-lasting limitations in activities and participation. Surgery is considered when conservative treatment fails to deliver relevant improvements or when neurological signs are severe. However, personalised multimodal physiotherapy may offer non-inferior outcomes to surgery, with possibly fewer adverse events and lower costs. Further research is needed to assess the (cost-)effectiveness of personalised multimodal physiotherapy compared to surgery. Methods: This randomised non-inferiority study compares personalised multimodal physiotherapy to anterior cervical discectomy with fusion (1:1 allocation ratio) among 126 patients with painful cervical radiculopathy having an indication for surgery, recruited by neurologists. Personalised multimodal physiotherapy uses a mechanism-based approach within a biopsychosocial framework and is tailored to the individual patient. The primary outcome is disability over 12 months using the neck disability index with a prespecified non-inferiority margin of three points. Secondary outcomes include arm and neck pain, fear of movement, and complications. Outcomes are measured at baseline and at three, six, nine, and 12 month follow-up. Additionally, a process evaluation and cost-effectiveness analysis will be performed. Data will be analysed according to the 'intention-to-treat' and the 'per-protocol' principle. Both will be conducted using linear and logistic mixed models. Ethics and dissemination: The study is approved by the medical ethics committee Brabant (P2327). Study registration number and status: The study protocol is registered at Open Science Framework (ID:S7HWA; registered June 27th, 2023). Recruitment commenced in May 2024. All data are anticipated to be collected by July 2027 when data analysis and interpretation will commence.

Indexed as

Cervical radiculopathyNeck painNeuropathic painPhysiotherapyRandomised controlled trialRehabilitationSurgery

Identifiers

PMID41858839
PMCPMC12996693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.