ArticleNature and science of sleep2026
Integrative Assessment of Cephalometric and Polysomnographic Features in Paediatric Obstructive Sleep Apnea: A Cross-Sectional Study.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to characterize pediatric patients with suspected sleep-disordered breathing (SDB) and evaluate whether cephalometric features and clinical indicators can predict obstructive sleep apnea (OSA) severity, as confirmed by polysomnography (PSG). Methods: A cross-sectional study was conducted among 228 children referred for sleep-related breathing concerns. Data collected included demographics, clinical symptoms (snoring, mouth-breathing, open-mouth posture, malocclusion), and cephalometric measurements (ANB, SNA, SNB angles, and nasopharyngeal soft tissue ratio). Overnight PSG assessed apnea-hypopnea index (AHI), rapid eye movement (REM) sleep proportion, and oxygen saturation. Children were classified as OSA-positive (AHI > 1 event/h) or non-OSA. Statistical analyses included t-tests, ANOVA, Pearson correlations, logistic regression, receiver operating characteristic (ROC) analysis, principal component analysis (PCA), and decision-tree modelling to identify predictors and stratify risk. Results: Among 228 children (mean age 7.4 ± 2.9 years; 62.7% male), 109 underwent PSG. The OSA group showed significantly higher ANB angles (5.8° ± 1.9 vs 3.9° ± 1.4, Conclusion: Pediatric OSA is strongly linked to craniofacial imbalance, adenoidal hypertrophy, and functional symptoms. Cephalometric parameters, particularly ANB angle and nasopharyngeal soft tissue ratio, combined with simple clinical indicators, offer reliable, low-cost screening for early OSA detection where PSG access is limited.
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