ArticlePatient preference and adherence2026
Pharmacist-Led Intervention to Enhance Direct Oral Anticoagulant Adherence and Treatment Outcomes in Atrial Fibrillation: A Pragmatic Clinical Trial.
Article in Patient preference and adherence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07159399 (Impact of a Pharmacist-Led Education Program on Medication Adherence and Treatment Effectiveness of Direct Oral Anticoagulants in Patients With Atrial Fibrillation), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of a Pharmacist-Led Education Program on Medication Adherence and Treatment Effectiveness of Direct Oral Anticoagulants in Patients With Atrial Fibrillation: A Randomized Controlled Trial
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Authors and funding
4 authors.
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Abstract
Purpose: This study aims to evaluate the impact of a pharmacist-led education program on medication adherence and treatment outcomes among patient with atrial fibrillation (AF) using direct oral anticoagulants (DOACs) for stroke prevention. Additionally, we will compare self-reported adherence with claims data and examine whether DOAC blood concentration can serve as a biomarker for medication adherence and treatment outcomes. Patients and Methods: We will conduct a pragmatic randomized controlled trial at National Taiwan University Hospital (NTUH). Patients aged 18 years or older, diagnosed with AF, and newly initiated on DOACs for primary or secondary stroke prevention will be randomized to either the intervention or control group. The intervention group will receive pharmacist-led education at baseline; the control group will receive usual care. The primary endpoint is patients' self-reported medication-use behavior, measured by the Traditional Chinese version of the Adherence to Refills and Medications Scale. We will also compare self-reported adherence with an objective adherence indicator, the DOAC trough concentration, determined by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. After randomization, participants will return to their routine clinical care, and all follow-up assessments will coincide with their regular clinic visits. Patients' DOAC use behaviors and blood concentrations will be measured at 3- and 6-month follow-ups. Baseline characteristics and treatment outcomes will be obtained from NTUH electronic medical records and the National Health Insurance claims data. Conclusion: This trial will evaluate the effectiveness of pharmacist-led education in improving DOAC adherence and treatment outcomes over a 6-month follow-up period. The findings will inform the development and implementation of future pharmacist-led care models. Trial Registration: The study protocol has been registered at ClinicalTrials.gov (identifier NCT07159399).
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