Evidence map›Paper›PMID 41858627›Full record

ArticleiScience2026

Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model.

Yike Yu, Jicong Du, Bendong Li, Ying Cheng, Fan Lin, Jiawei Zhou, Yihang Song, Cong Liu, Shengyun Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yike YuDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Jicong DuFaculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
Bendong LiDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Ying ChengFaculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
Fan LinDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Jiawei ZhouDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Yihang SongDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Cong LiuFaculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
Shengyun CaiDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic radiotherapy, a key treatment for pelvic malignancies, frequently causes iatrogenic premature ovarian insufficiency (POI) in young female patients, highlighting the urgent need for targeted, effective, and low-toxic radioprotectants. Zymosan-A, a TLR2/6 agonist, has potential radioprotective effects. We established a

Indexed as

biological sciencesfemale reproductive endocrinologyhealth sciencestherapeutics

Identifiers

PMID41858627
PMCPMC12995874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.