Evidence map›Paper›PMID 41858621›Full record

ArticleiScience2026

Multidimensional cfRNA response modeling identifies a 5-gene pair signature for high-robust pulmonary tuberculosis diagnosis.

Changchun Wu, Huiyuan Qiao, Xianrun Pan, Hongyan Lin, Xueqin Xie, Mengze Du, Hao Lin, Jian Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Changchun WuThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Huiyuan QiaoThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Xianrun PanThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Hongyan LinThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Xueqin XieThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Mengze DuSchool of Healthcare Technology, Chengdu Neusoft University, Chengdu 611844, China.
Hao LinThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Jian HuangThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lack of non-invasive biomarkers hinders pulmonary tuberculosis (PTB) management. We developed a multidimensional machine learning framework to systematically evaluate five cell-free RNA (cfRNA)-derived host response modalities: immune cell infiltration, global transcriptional perturbation (expression- and rank-based), key genes, and gene pairs. While immune-cell and global perturbation models showed moderate efficacy, an optimized 5-gene pair classifier demonstrated robust diagnostic power. This signature achieved an AUC of 0.947 in the validation subset derived from the parent study and maintained 100% sensitivity (95% CI: 0.741-1.000) in HIV-coinfected individuals. Model scores correlated significantly with bacterial load (

Indexed as

Health sciences

Identifiers

PMID41858621
PMCPMC12995876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.