Evidence map›Paper›PMID 41858618›Full record

ReviewiScience2026

Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications.

Yumo Zhou, Yanfu Wang, Yixi Wu, Zhuhao Zhang, Yuwen Zhang, Chenghao Chen, Yiqin Chen, Yanjun Zhang, Lei Fang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yumo ZhouSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.
Yanfu WangDepartment of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yixi WuDepartment of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zhuhao ZhangDepartment of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yuwen ZhangSchool of Public Health, Hangzhou Medical College, Hangzhou, China.
Chenghao ChenSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.
Yiqin ChenUniversity College London, London, UK.
Yanjun ZhangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Lei FangDepartment of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (DBV), is an emerging vector-borne infection with significant global health implications, particularly in East Asia. In recent years, its geographic footprint has expanded beyond traditional endemic regions, raising global concern due to high morbidity and variable case-fatality rates of up to 30%. Clinically, SFTS presents with an acute onset of high fever, thrombocytopenia, leukocytopenia, headache, and gastrointestinal disturbances. In severe cases, rapid progression may lead to life-threatening complications, including myocarditis, neurological disorders, invasive pulmonary aspergillosis (IPA), secondary infections, systemic inflammatory response syndrome (SIRS), hemophagocytic lymphohistiocytosis (HLH), and ultimately multi-organ failure (MOF). This review synthesizes recent advances in virology, pathophysiological mechanisms, diagnostic strategies, and therapeutic interventions for DBV infections. Special attention is given to the complications most commonly associated with poor prognoses and fatal outcomes in patients with SFTS, alongside future outlooks for research and public health preparedness to mitigate the growing global burden of this high-priority tick-borne disease.

Indexed as

Health sciences

Identifiers

PMID41858618
PMCPMC12995709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.