ArticleiScience2026
EFA6A regulates retinal function through the control of photoreceptor cell activity and structure.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
The initial step in visual perception, i.e., the collection of light, is carried out by the outer segments of photoreceptor cells. These outer segments, specialized primary cilia, house the photopigments that absorb photons. Here, we report that EFA6A, an exchange factor for the small G protein Arf6, previously described as a regulator of early ciliogenesis by promoting distal appendage vesicle fusion, is essential for visual function. We demonstrate that EFA6A is present in various layers of the mouse retina, including the photoreceptors and the retinal pigment epithelium (RPE). Accordingly, depletion of EFA6A in the mouse retina leads to both morphological and functional defects in photoreceptors, resembling the phenotypes observed in retinal ciliopathies. We also show that EFA6A depletion in RPE cells severely impairs their phagocytic activity. Thus, our results point out a key role for EFA6A in the control of visual activity.
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