Evidence map›Paper›PMID 41858441›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Multidimensional characterization of allergic rhinitis in Mysuru, South India: A cluster-based approach.

Padukudru Anand Mahesh, Attahalli Shivanarayanprasad Praveena, Mohammed Kaleem Ullah, Mandya Venkateshmurthy Greeshma, Jayaraj Biligere Siddaiah, Jefferson Daniel, Devasahayam Jesudas Christopher, Krishnarajah Nirantharakumar, Adel H Mansur, Glenis Scadding and 2 more

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Aeroallergen Sensitization Phenotypes and Multimorbidity in Allergic Rhinitis and Asthma: A Large Urban Cluster Analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Padukudru Anand MaheshDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, India.
Attahalli Shivanarayanprasad PraveenaDepartment of Studies in Statistics, University of Mysore, Mysuru, India.
Mohammed Kaleem UllahDepartment of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru, India.
Mandya Venkateshmurthy GreeshmaCenter of Excellence in Molecular Biology and Regenerative Medicine Laboratory (DST-FIST Supported Center and ICMR Collaborating Center of Excellence), Department of Biochemistry (DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, India.
Jayaraj Biligere SiddaiahDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, India.
Jefferson DanielDepartment of Pulmonology, Christian Medical College, Vellore, India.
Devasahayam Jesudas ChristopherDepartment of Pulmonology, Christian Medical College, Vellore, India.
Krishnarajah NirantharakumarDepartment of Applied Health Research, School of Health Sciences, University of Birmingham, Birmingham, United Kingdom.
Adel H MansurDepartment of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Glenis ScaddingDepartment of Allergy, Immunology and Rhinology, Royal National ENT Hospital, London, United Kingdom.
David C WraithDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, United Kingdom.
Mamidipudi Thirumala KrishnaDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Allergic rhinitis (AR) affects approximately 10% of Indian adults, but its clinical and biological heterogeneity remains poorly defined. Objective: We sought to characterize AR phenotypes in South Indian adults using clinical features, spirometry, fractional exhaled nitric oxide (Feno), skin prick tests, blood biomarkers, and cluster analysis. Methods: This was a prospective observational study of 122 patients (≥18 years old) with AR with or without asthma attending a South Indian tertiary allergy clinic and 50 asymptomatic nonatopic control subjects. Participants underwent standardized symptom/exposure assessments, spirometry, Feno, blood counts, serum IgE, and skin prick tests to 10 aeroallergens. Principal component analysis, correlation networks, and unsupervised k-means clustering were applied to define phenotypes. Results: Patients with AR were younger than control subjects, predominantly female, and frequently exposed to incense and mosquito repellents. Sensitization to house dust mite (>70%) and polysensitization were common. Compared with control subjects, patients with AR had elevated Feno (43 vs18 ppb; Conclusions: This study showed 3 distinct AR clusters with high dust mite sensitization alongside cosensitization with cockroach, weed, and Bermuda pollens. Multicenter studies are warranted to further refine AR clusters, including tissue-level biomarker profiling and relevance to pharmacotherapy and immunomodulatory therapies.

Indexed as

Allergic rhinitiscluster analysishouse dust miteIndiaphenotypes

Identifiers

PMID41858441
PMCPMC12995828

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.