Evidence map›Paper›PMID 41858363›Full record

ArticleFrontiers in oncology2026

A comparative dosimetric evaluation of two image-guided calibration strategies for multi-isocenter total body irradiation: integrated fan-beam CT-based alignment versus sequential cone-beam CT-guided localization.

Bo Gao, Yaling Hong, Junjing Yan, Xiwei Chen, Suhua Tan, Yutao Zhu, Yan Liu, Zhaojie Yao, Lizhen Wu, Haiyan Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo Gao *Department of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Yaling Hong *Department of Radiation Oncology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Institute, Shanghai, China.
Junjing YanDepartment of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Xiwei ChenHunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, Hunan, China.
Suhua TanDepartment of Radiation Oncology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Institute, Shanghai, China.
Yutao ZhuDepartment of Radiation Oncology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Institute, Shanghai, China.
Yan LiuDepartment of Radiation Oncology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Institute, Shanghai, China.
Zhaojie YaoDepartment of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Lizhen WuDepartment of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Haiyan ChenDepartment of Radiation Oncology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Institute, Shanghai, China.
Zhanquan LeiDepartment of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Image-guided radiotherapy (IGRT) is key to making sure the radiation dose is accurate when treating kids with multi-isocenter total body irradiation (TBI). Ensuring dose accuracy in pediatric multi-isocenter TBI. Shanghai Children's Medical Center employed low-dose fan-beam CT (FBCT) for integrated multi-isocenter calibration, whereas Fujian Children's Hospital used cone-beam CT (CBCT) for sequential isocenter alignment. Objective: To evaluate FBCT versus CBCT guidance effects on target coverage and organ doses across two regimens: 12 Gy in 6 fractions and 3 Gy in 1 fraction. Methods: Retrospective analysis of 34 pediatric TBI patients (21 FBCT, 13 CBCT) treated with identical field setups (three upper-body isocenters; two/three lower-body isocenters; junction at upper femur third). Pre-treatment FBCT/CBCT images were registered to planning CTs; doses recalculated using original plans. Metrics: PTV V90%, V100%, V110%, mean doses; homogeneity index (HI); conformity index (CI); mean lung and kidney doses. Results: In the 12 Gy group, FBCT guidance improved PTV coverage: V Conclusion: FBCT guidance gave better target dose conformity and homogeneity, and lower lung doses, than CBCT guidance-both for the 12 Gy myeloablative regimen and the 3 Gy low-dose regimen. These results suggest that FBCT guidance is a better option for image-guided total body irradiation in children.

Indexed as

childrencone-beam CTdosimetryfan-beam CTimage guidancetotal body irradiation

Identifiers

PMID41858363
PMCPMC12995668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.