ArticleFrontiers in oncology2026
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Radiotherapy is an important treatment for lung cancer. However, in the course of radiotherapy, treatment-related side effects and decreased radiosensitivity remain challenging issues. TGF-βR1 can induce radiation-induced bystander effect (RIBE) through the primary cilia; however, this mechanism needs to be further elucidated. At present, traditional Chinese medicine (TCM) shows great advantages in protecting against RIBE, in which Methods: A co-culture model of A549 cells and bone marrow mesenchymal stem cells (BMSCs) was established, and network pharmacology was employed to identify key proteins involved in the repair of radiation-induced DNA damage in BMSCs. The role of the primary cilium/TGF-βR1 pathway in the repair of radiation-induced DNA damage in adjacent BMSCs was investigated using immunofluorescence and Western blot techniques. Molecular docking technology was utilized to screen effective small molecules from Results: The core differentially expressed gene IFT88 was identified by bioinformatics analysis. In the co-culture model with BMSCs following A549 irradiation with 2 Gy of X-ray, BMSCs were inhibited. After irradiation, TGF-βR1, IFT88, and RAD51 were abnormally activated in the adjacent BMSCs. However, after knockdown of IFT88 (SiIFT88), the protein expressions of TGF-βR1 and RAD51 were significantly decreased. Based on molecular docking screening for TGF-βR1 and IFT88 using the Conclusion: Primary cilia play a key role in the repair of radiation-induced DNA damage in adjacent BMSCs and in enhancing the radiosensitivity of lung cancer. Vanillic acid and rosewood in
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