ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Inter-Organelle Membrane Contact Sites as Physiological Regulatory Hubs in the Brain: From Neurons to Glial Cells.Biomolecules · 2026Review
- Heat Stress in the Liver of Chicken: Insights from Keap1-Nrf2 Pathway Mediated Ferroptosis and Cuproptosis via the HO-1/FDX1/Gpx4 Axis.Veterinary sciences · 2026Article
- Stage-associated immunoproteomic profiling of serum autoantibody-captured retinal antigens in age-related macular degeneration.Frontiers in immunology · 2026Article
- Doxorubicin-induced cardiotoxicity: Is ferroptosis the primary driver or a downstream amplifier?EXCLI journal · 2026Review
- Reactive Oxygen Species: Molecular Mechanisms, Cellular Targets, and Implications for Genomic Stability.BioMed research international · 2026Review
- Ferroptosis in metabolic dysfunction-associated steatotic liver disease.Frontiers in immunology · 2026Review
- Triterpenoid saponins and ferroptosis: A membrane centered perspective.EXCLI journal · 2026Article
- Novel insights of ferroptosis in atherosclerosis progression.Frontiers in cell and developmental biology · 2026Review
- [Research progress on the pathological mechanisms and clinical translation of ferroptosis in necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ferroptosis is a form of regulated cell death driven by iron-dependent peroxidation of polyunsaturated phospholipids. The susceptibility of cells to ferroptosis is often strongly shaped by lipid metabolic pathways that determine the abundance, distribution, and redox reactivity of polyunsaturated phospholipids. Enzymes that activate and incorporate polyunsaturated fatty acids into phospholipids generate the substrates whose peroxidation causes ferroptosis, thereby sensitizing cells to ferroptosis. In contrast, synthesis of monounsaturated phospholipids and the presence of lipid-soluble antioxidants limit the accumulation of phospholipid peroxides, thereby protecting cells from ferroptosis. Thus, different tissues may display characteristic ferroptotic responses caused by their unique lipid composition and antioxidant capacity. This review summarizes the metabolic foundations that determine the susceptibility of cells to ferroptosis and discusses the possibility of treating human diseases by modulating cellular sensitivity to ferroptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.