Evidence map›Paper›PMID 41858268›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Chemically Engineered L. reuteri Delivering αPD-L1 and Gallium Ions via Metal-Phenolic Networks Potentiate Anti-Tumor Immunity and Ferroptosis.

Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingting ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Mengyi XuInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yan ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhiwen LiInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China.
Danqing SongInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jing PangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ke LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yanxiang WangInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China.ORCID https://orcid.org/0009-0003-5393-1466

Funding

Institute of Health and Medicine, Hefei Comprehensive National Science Center Foundation 2024KYQD011National Natural Science Foundation of China 32141003National Natural Science Foundation of China 82525066
6 · The paper itself

Abstract

Bacterial-based materials, leveraging their inherent hypoxia and immunosuppressive microenvironment-targeting capabilities, immunomodulatory effects, and drug delivery advantages, have emerged as promising strategies to modulate the tumor microenvironment (TME) for converting immunologically "cold" tumors into "hot" ones. This study innovatively functionalizes Lactobacillus reuteri (L. reuteri) using metal-phenolic networks (MPNs) to co-deliver αPD-L1 antibodies and gallium ions (Ga

Indexed as

B7-H1 AntigenFerroptosisGalliumLimosilactobacillus reuteriAnimalsMiceMice, Inbred C57BLTumor MicroenvironmentB7-H1 AntigenCd274 protein, mouseGalliumBacterial‐based materialsferroptosisimmune microenvironmentmetal‐phenolic networkssynergistic tumor regression

Identifiers

PMID41858268
PMCPMC13588008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.