ArticleGenetics research2026
Molecular Subtype Classification and Mechanistic Investigation Based on Ferroptosis-Related lncRNAs in Ovarian Cancer.
Article in Genetics research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Subtype Classification and Mechanistic Investigation Based on Ferroptosis-Related lncRNAs in Ovarian Cancer.Genetics research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Ovarian cancer (OC) ranks among the most prevalent malignant tumors in women, contributing significantly to mortality rates. This disease exhibits considerable heterogeneity, characterized by intricate molecular and genetic alterations. Ferroptosis, a distinct form of cell death, has emerged as a critical factor in various cancers, including OC. However, the regulatory mechanisms underlying ferroptosis in OC patients remain unclear and require further investigation. This study aimed to identify lncRNA associated with OC and elucidate the underlying mechanisms through bioinformatics methods and experimental validation. Ferroptosis-related lncRNAs (FRLs) was identified in OC, and its prognostic value was assessed using univariate Cox analysis. Additionally, the molecular subtypes of FRLs were evaluated through the ConsensusClusterPlus software package. Notably, Cluster 2 exhibited a low TME score, which was linked to a poorer prognosis. The GSEA suggested that Cluster 2 shared similarities with other clusters associated with worse survival outcomes, likely due to the activation of tumor-associated pathways. In vitro experiments further confirmed that certain lncRNAs could be upregulated under ferroptotic conditions. We focused on two lncRNAs, AC027348.1 and TRAM2-AS1, which were not noticed before and were significantly upregulated, to explore their regulatory effects on ferroptosis. The underlying mechanisms were preliminarily investigated through transcriptome sequencing. In summary, our findings offer new insights into the pathogenesis of OC, particularly regarding the role of lncRNAs related to ferroptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.