Evidence map›Paper›PMID 41858210›Full record

SynthesisJournal of sleep research2026

CPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs.

Jenny Theorell-Haglöw, Yüksel Peker, Nathaniel S Marshall

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jenny Theorell-HaglöwDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2819-2799
Yüksel PekerDepartment of Pulmonary Medicine, Koc University School of Medicine, Istanbul, Turkey.ORCID 0000-0001-9067-6538
Nathaniel S MarshallCentre for Research and Understanding of Sleep (CIRUS), Woolcock Institute for Medical Research, Macquarie University, Sydney, Australia.ORCID 0000-0002-9014-1397

Funding

The Swedish Heart Lung Foundation 20190607The Swedish Heart Lung Foundation 20190611
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) has been hypothesised to promote cancer via intermittent hypoxia, and assessing what happens when OSA is controlled by continuous positive airway pressure (CPAP) may provide valuable insight. We conducted a meta-analysis of three randomised controlled trials (SAVE, RICCADSA, ISAACC) assessing cancer incidence from adverse event data on neoplasms among OSA patients randomised to continuous positive airway pressure (CPAP) versus control. Across trials, cancer incidence was similar between groups, and meta-analysis showed no statistically significant difference (CI 0.55-1.68). Treating sleep apnea with CPAP does not appear to markedly reduce the risk of incident cancers.

Indexed as

Continuous Positive Airway PressureNeoplasmsSleep Apnea, ObstructiveHumansRandomized Controlled Trials as TopiccancerCPAPobstructive sleep apnea

Identifiers

PMID41858210
PMCPMC13003302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.