Evidence map›Paper›PMID 41858208›Full record

ArticleJournal of sleep research2026

Rest-Activity Rhythms and Cognition in Older Adults With and Without Insomnia.

Miranda G Chappel-Farley, Zhiwei Zhao, Christine W Johnston, Shuo Chen, Avelino C Verceles, Valerie E Rogers, Daniel J Buysse, Emerson M Wickwire, Kristine A Wilckens

Abstract read
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miranda G Chappel-FarleyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1349-0507
Zhiwei ZhaoDepartment of Mathematics, University of Maryland College Park, College Park, Maryland, USA.
Christine W JohnstonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland, USA.
Shuo ChenDivision of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland, USA.
Avelino C VercelesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland, USA.
Valerie E RogersRetired, USA.
Daniel J BuysseDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Emerson M WickwireDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland, USA.
Kristine A WilckensDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Funding

Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5M
Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL)R01AG080609 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI OSORIO, RICARDO S, STONE, KATIE L · 2023 to 2024
$7.4M
Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
The impact of central sleep apnea in patients receiving medications for opioid use disorderR01DA059465 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sanjay R Patel · 2023 to 2026
$4.1M
Physical Activity and Dementia: Mechanisms of ActionR35AG072307 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2021 to 2025
$3.6M
Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-betaR01AG068001 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILCKENS, KRISTINE ANN · 2021 to 2025
$3.4M
Merck Investigator Studies Program 59170NHLBI NIH HHS T32 HL082610NHLBI NIH HHS T32HL082610NIA NIH HHS P01AG025204NIA NIH HHS R01 AG068001NIA NIH HHS R01AG068001NIA NIH HHS R01AG080609NIA NIH HHS R35AG072307NIDA NIH HHS R01DA059465NIH HHS
6 · The paper itself

Abstract

Insomnia is associated with risk for cognitive deficits. However, the literature assessing cognitive impairments in insomnia is replete with conflicting findings; it is unclear whether individuals with insomnia exhibit impaired cognition or whether specific sleep features consistently predict cognitive performance in insomnia. Disturbance in rest-activity rhythms may be more directly associated with cognitive deficits in insomnia. In a sample of older adults with (n = 30) and without insomnia (n = 33), we examined (1) whether insomnia diagnosis was associated with differences in rest-activity rhythms and cognition, and (2) whether rest-activity rhythms were associated with cognition across domains. We used a remote comprehensive cognitive battery to test four domains of cognition: attention, inhibition, cognitive flexibility, and episodic memory. Compared to older adults without insomnia, older adults with insomnia exhibited attenuated rest-activity rhythms, indicated by lower relative amplitude (F

Indexed as

CognitionRestSleep Initiation and Maintenance DisordersAgedAged, 80 and overAttentionCognitive FlexibilityFemaleHumansInhibition, PsychologicalMaleMemory, EpisodicNeuropsychological Testsagingattentioncognitioninsomniarest‐activity rhythmssleep

Identifiers

PMID41858208
PMCPMC13003282

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.