ArticleInternational journal of surgical pathology2026
Evaluation of Phosphohistone H3 in Assessment of Mitotic Activity in Invasive Breast Carcinoma: A Correlative Study With Ki-67 and Histologic Grade.
Article in International journal of surgical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundAccurate assessment of tumor proliferation is vital for grading breast cancers, which impacts prognosis. Phosphohistone H3 (PHH3) is a mitotic figure-specific immunohistochemical (IHC) marker. This study aims to evaluate the utility of PHH3 in detecting mitotic figures in invasive breast carcinoma in comparison to the conventional counting on hematoxylin and eosin (H&E) slides and its correlation with Ki-67 index, histological grade, and other clinicopathological parameters.Materials and methodsThe study was conducted on 100 mastectomy specimens with breast cancers. Tumors were graded using the Nottingham grading system. IHC staining was performed for PHH3 and Ki-67.ResultsIn 40% of specimens, the PHH3 score was elevated (>13 mitotic figures per 10 HPF). PHH3 identified significantly higher mitotic figures than conventional H&E (14 vs 7/10 HPF) and this led to a shift toward higher grades. By H&E, 41% of tumors were grade 2, 40% grade 1, and 19% grade 3. After the PHH3 reassessment, grade 1 dropped to 34%, while grade 3 rose to 31%. PHH3 score significantly correlated with mitotic score on H&E (
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