Evidence map›Paper›PMID 41858117›Full record

ReviewGenome biology and evolution2026

Caution in Interpreting Regulatory RNA Associations With Eusocial Evolution in Bees.

Petr Heneberg

Abstract readReview
In one paragraph

Review in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Genome Evolution in Social Insects.Genome biology and evolution · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Petr HenebergThird Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-0703-951X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in transcriptomics and regulatory genomics have expanded interest in the potential roles of alternative splicing and noncoding RNAs in the evolution of eusociality in bees. A recently published review by Brenman-Suttner and Zayed synthesized this literature, highlighting numerous associations between the expression patterns of regulatory RNA and caste, task, and developmental states. However, there is a distinction between molecular associations and demonstrated causal roles in evolutionary processes, particularly for complex social traits. Drawing on established principles from evolutionary genomics and regulatory biology, we discuss the limitations of correlational transcriptomic data and highlight ongoing debates over the functional inference of circular RNAs and long noncoding RNAs. Clarifying these interpretive boundaries is essential for aligning conclusions with current evidence and for guiding future experimental research on the molecular basis of social evolution.

Indexed as

BeesEvolution, MolecularSocial EvolutionAlternative SplicingAnimalsRNARNA, Long NoncodingRNA, UntranslatedTranscriptomeRNARNA, Long NoncodingRNA, Untranslatedcircular RNAeusocialityevolutionHymenopteralong noncoding RNAregulatory RNA

Identifiers

PMID41858117
PMCPMC13002560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.