Evidence map›Paper›PMID 41857825›Full record

ArticleBMJ open2026

Design and rationale of the EFFORTII project: a multicentric randomised-controlled trial on the impact of continued nutritional therapy at hospital discharge.

Carla Wunderle, Pascal Tribolet, Nina Kaegi-Braun, Valerie Haller, Robert Escher, Drahomir Aujesky, Gisele Trennepohl Da Costa Heinen, Michael Brändle, Thomas Bregenzer, Christoph Henzen and 13 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04926597 (Effect of Continued Nutritional Support at Hospital Discharge on Mortality, Frailty, Functional Outcomes and Recovery Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04926597 narecruitingnot on this map

Effect of Continued Nutritional Support at Hospital Discharge on Mortality, Frailty, Functional Outcomes and Recovery Trial: The EFFORT II Project

TypeinterventionalSponsorPhilipp SchuetzRan2021 to 2026Enrolled1,200ConditionsMalnutritionArmsnutritional supplement, individualized nutritional guidelines, general nutritional information
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Carla WunderleMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau AG, Aarau, Switzerland carla.wunderle@ksa.ch.ORCID http://orcid.org/0000-0003-1720-6462
Pascal TriboletMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau AG, Aarau, Switzerland.
Nina Kaegi-BraunDepartment of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Valerie HallerMedical University Department, Kantonsspital Aarau, Aarau, Switzerland.ORCID http://orcid.org/0009-0007-1599-7850
Robert EscherDepartment of Medicine, Spital Emmental, Burgdorf, Switzerland.
Drahomir AujeskyDivision of Diabetes, Endocrinology, Nutritional Medicine, and Metabolism, Bern University Hospital, Bern, Switzerland.
Gisele Trennepohl Da Costa HeinenDepartment of Endocrinology, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Michael BrändleDepartment of General Internal Medicine / Family Medicine and Emergency Medicine, HOCH Health Eastern Switzerland, St. Gallen, Switzerland.
Thomas BregenzerMedical Department, Spital Lachen AG, Lachen, Switzerland.
Christoph HenzenMedical Department, Luzerner Kantonsspital, Lucerne, Switzerland.
Thomas ZehnderMedical Department, Spital Thun, Thun, Switzerland.
Susanne SchaitDepartment of Anesthesiology and Critical Care Medicine, Klinik Hirslanden, Zürich, Switzerland.
Christina GassmannDepartment of Nursing and Allied Health Care Professions, University Hospital Zurich, Zürich, Switzerland.
Maja DorfschmidClinic for Visceral, Thoracic, Vascular Surgery, and Angiology, Stadtspital Zürich Triemli, Zürich, Switzerland.
María D Ballesteros-PomarDepartment of Endocrinology and Nutrition, Complejo Asistencial Universitario de León, Leon, Spain.
Cristina CuerdaDepartamento de Medicina, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rosa BurgosNutritional Support Unit, University Hospital Vall d'Hebron, Madrid, Spain.
Daniel De LuisServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid and Health Research Institute of Valladolid (IBioVALL), Valladolid, Spain.
Gabriel OlveiraServicio de Endocrinología y Nutrición, ospital Regional Universitario e instituto de investigación biomédica de Málaga, Malaga, Spain.
Leocardio Rodriguez-MañasCentro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Zeno StangaDivision of Diabetes, Endocrinology, Nutritional Medicine, and Metabolism, Inselspital Universitatsspital Bern, Bern, Switzerland.
Beat MuellerMedical University Department, Kantonsspital Aarau AG, Aarau, Switzerland.
Philipp SchuetzMedical University Department, Kantonsspital Aarau, Aarau, Switzerland.ORCID http://orcid.org/0000-0002-3799-3742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalnutrition is a highly prevalent chronic condition that contributes to higher morbidity and mortality in patients with multiple comorbidities. While positive effects of nutritional therapy in the in-hospital setting have recently been demonstrated, the benefits of long-term nutritional therapy after hospital discharge remain uncertain. Herein, we outline the design and rationale of the EFFORTII trial, the largest nutritional trial to date to assess the effects of continued nutritional support after hospital discharge in medical patients, with particular attention to key design decisions regarding nutritional strategy, patient selection criteria and study endpoints. METHODS AND ANALYSIS: The ETHICS AND DISSEMINATION: This study involves human participants and was first granted ethical approval by the Ethics Committee Northwest- and Central Switzerland and then by all participating local ethics committees. Written informed consent will be obtained from all participants. Findings will be disseminated in peer-reviewed journals and academic conferences. TRIAL REGISTRATION NUMBER: NCT04926597.

Indexed as

MalnutritionNutritional SupportNutrition TherapyPatient DischargeChronic DiseaseHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicResearch DesignINTERNAL MEDICINENutritional supportNUTRITION & DIETETICSRandomized Controlled TrialTreatment Outcome

Identifiers

PMID41857825
PMCPMC13007153

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.