ArticleBiomarker research2026
A global multidimensional analysis of the chimeric antigen receptor T-cell therapy clinical trial landscape and development trends.
Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Chimeric antigen receptor T-cell (CAR-T) therapy has advanced significantly in oncology. To reveal the main trends affecting this field, we collected trial information of 1,908 CAR-T clinical trials using the INFORMA database. Since 2010, the number of CAR-T trials has increased sharply. China (1,006 trials) and the United States (549 trials) accounted for over 80% of all studies. Only 4.2% were sex-restricted studies and only 22% involved children. Although most studies were early phase, the number of phase III/IV trials has been steadily increasing. Research has predominantly focused on hematologic malignancies, including non-Hodgkin lymphoma, acute lymphoblastic leukemia, and multiple myeloma. While progress in solid tumors has been comparatively slower, it is steadily advancing. In addition, CAR-T therapy has demonstrated potential in treating certain autoimmune diseases. While CD19 molecule and TNF receptor superfamily member 17 remain dominant targets, other targets-including mesothelin and claudin 18 for solid tumors-were increasingly investigated. Several approved CAR-T products, such as Axicabtagene ciloleucel and Tisagenlecleucel, have undergone numerous clinical trials, resulting in expanded indications and refined treatment strategies. These findings offer some valuable insights into the status and prospects of CAR-T clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.