Evidence map›Paper›PMID 41857704›Full record

ArticleBMC microbiology2026

Characteristics of RNA viruses in rodents across different ecological regions of Yunnan and analysis of their evolutionary patterns and replication potential.

Yutong Hou, Yayu Fan, Jiuxuan Zhou, Lulu Deng, Qian Li, Xiang Le, Yuting Ning, Yi Xuan Wang, Xuanjiang Liu, Xiaoli Wan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yutong Hou *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Yayu Fan *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Jiuxuan ZhouYunnan Academy of Forestry and Grassland, Kunming, 650000, Yunnan, P.R. China.
Lulu DengFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Qian LiFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Xiang LeFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Yuting NingFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Yi Xuan WangYunnan Academy of Forestry and Grassland, Kunming, 650000, Yunnan, P.R. China.
Xuanjiang LiuFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Xiaoli WanFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Xinrui WuFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China.
Binghui WangYunnan Province Key Laboratory of Public Health and Biosafety, School of Public Health, Kunming Medical University, Kunming, 650000, Yunnan, P.R. China. binghuiwang@aliyun.com.
Xueshan XiaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650000, Yunnan, P.R. China. oliverxia2000@aliyun.com.

Funding

Joint project of the Department of Science and Technology of Yunnan Province and Kunming Medical University 202501AY070001-026National Natural Science Foundation of China 82460392The Youth Talent Program of Yunnan 'Ten-thousand Talents Program The Youth Talent Program of Yunnan 'Ten-thousand Talents ProgramYunnan Key R&D Program 202502AA310014-1
6 · The paper itself

Abstract

backgroundRodents are reservoirs of zoonotic viruses that significantly threaten public health. This study investigated the RNA virome of 624 rodents collected across six ecological zones in Yunnan Province, China, using meta-transcriptomic analyses to explore viral diversity, regional distribution, and evolutionary characteristics.

resultsHigher virome diversity was observed in the north-eastern and central Yunnan Plateaus, and lower diversity was observed in the north-western cold-temperate region. Phylogenetic analyses identified a unique Seoul virus lineage that represents an ancestral strain, while highlighting cross-species transmission events. Arenaviridae and Coronaviridae exhibited enrichment in specific regions, and tissue-specific viral preferences were observed, such as rotavirus in the gut tissues and Seoul virus in the lung tissues. Four zoonotic viral strains were isolated and demonstrated efficient replication in rodent cells, with limited adaptability in human cell lines.

conclusionsThese findings underscore the importance of ecological factors in shaping viral evolution and highlight the need for continuous surveillance.

Indexed as

Evolution, MolecularRNA VirusesRodentiaVirus ReplicationAnimalsChinaHumansPhylogenyRNA, ViralViromeRNA, ViralDisease surveillanceMeta-transcriptomic analysis; RNA viromeRodentViral evolutionZoonotic risk

Identifiers

PMID41857704
PMCPMC13123065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.