Evidence map›Paper›PMID 41857562›Full record

ArticleBMC biotechnology2026

Periodontal ligament stem cells-loaded photocrosslinking GelMA/PEGDA scaffolds for periodontal bone regeneration.

Bei Gao, Jie Yao, Yijie Wang, Chen Chen, Zhen Chai, Wanting Wan, Shiyang Wu, Zhongbo Liu, Rui Zou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bei Gao *Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Jie Yao *Clinical Research Centre of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Yijie Wang *Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Chen ChenKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Zhen ChaiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Wanting WanKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Shiyang WuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China.
Zhongbo LiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China. liuzb727@xjtu.edu.cn.
Rui ZouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China. rainy@xjtu.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China No. 82370997The Natural Science Basic Research Program of Shaanxi Province 2023-JC-YB-813
6 · The paper itself

Abstract

backgroundMatrix stiffness is a key feature of the mechanical microenvironment. Periodontal tissue is a multicomponent structure composed of cementum, periodontal ligament, and alveolar bone, and is essential for the physiological reconstruction and stress of teeth. Simulating the stiffness of periodontal tissue with a biomimetic extracellular matrix is ​​of great significance for regulating cell behavior and tissue repair. In this study, the application of GelMA-PEGDA hybrid hydrogels with different matrix stiffnesses for periodontal bone regeneration was explored.

resultsIn this work, a GelMA‒PEGDA hybrid hydrogel ink was prepared, and the proportion of PEGDA significantly increased the matrix stiffness of the hybrid hydrogel, which had good biocompatibility. In addition, matrix stiffness promoted the osteogenic differentiation and mineralization capacity of periodontal ligament stem cells on the surface of the gels. A high-precision hydrogel scaffold was obtained by introducing a photoinhibitor. The porosity and biocompatibility of the scaffold were good.

conclusionsThis 3D-printed hydrogel provides a promising strategy for periodontal bone tissue regeneration.

Indexed as

Bone RegenerationGelatinPeriodontal LigamentPolyethylene GlycolsStem CellsTissue ScaffoldsBiocompatible MaterialsCell DifferentiationCells, CulturedHumansHydrogelsMethacrylatesOsteogenesisPrinting, Three-DimensionalTissue EngineeringBiocompatible MaterialsGelatingelatin methacryloylHydrogelsMethacrylatespoly(ethylene glycol)diacrylatePolyethylene GlycolsGelMA-PEGDA hydrogelHuman periodontal ligament stem cellsMatrix stiffnessPeriodontal bone regenerationStereolithography 3D printing

Identifiers

PMID41857562
PMCPMC13123019

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