Evidence map›Paper›PMID 41857414›Full record

ArticleNature microbiology2026

LRP8 is a functional receptor for yellow fever virus.

Miao Mei, Yang Yang, Zihan Zhang, Yue Yin, Jiali Tan, Chao Jiang, Yu Gao, Zhaoyang Wang, Donghong Wang, Yajing Li and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dengue virus infection.Nature reviews. Disease primers · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Miao Mei *Beijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Yang Yang *Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-6489-4459
Zihan Zhang *State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Yue YinShenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Jiali TanBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Chao JiangBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Yu GaoBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Zhaoyang WangNew Cornerstone Science Laboratory, Beijing Key Laboratory of Viral Infectious Diseases, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Donghong WangSchool of Medicine, Tsinghua University, Beijing, China.
Yajing LiBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Yingyi CongBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Zhiyuan ZhangBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.
Yousong PengBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.ORCID http://orcid.org/0000-0002-5482-9506
Wenjie TanNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID http://orcid.org/0000-0002-5963-1136
Jiandong LiNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Li LiChinese Institute for Cancer Research, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Hanxuan WangDivision of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Ren LangDivision of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Qiang HeDivision of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Zihou DengChinese Institute for Cancer Research, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China.ORCID http://orcid.org/0009-0007-2743-668X
Xiaojie HuangBeijing Youan Hospital, Capital Medical University, Beijing, China.
Bin LuoChinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Chao ShanState Key Laboratory of Virology and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.ORCID http://orcid.org/0000-0002-3953-3782
Yonghong ZhangBeijing Youan Hospital, Capital Medical University, Beijing, China.
Lin MeiChinese Institutes for Medical Research, Capital Medical University, Beijing, China.
Gong ChengNew Cornerstone Science Laboratory, Beijing Key Laboratory of Viral Infectious Diseases, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-7447-5488
Xu TanBeijing Key Laboratory of Autoimmune Disease Mechanism Research and Novel Drug Development, Chinese Institute for Immunology, Chinese Institutes for Medical Research, Capital Medical University, Beijing, China. xtan@cimrbj.ac.cn.ORCID http://orcid.org/0000-0003-4861-4573

Funding

Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2021YFA1302503 and 2022YFE0102200
6 · The paper itself

Abstract

Yellow fever virus (YFV) is an arbovirus causing substantial human morbidity and mortality. The live-attenuated 17D strain serves as vaccine and is one of the most successful vaccines so far. Receptor usage between attenuated and pathogenic YFV strains remains unclear. Here we performed a barcoded, genome-wide human open-reading frame library screen and identified LRP8 (also named APOER2) as a receptor for YFV. We show that LRP8 expression increases YFV infection (17D and two clinical strains, BJ01 and Asibi) in cell lines by promoting entry. Adeno-associated virus-mediated expression of human LRP8 in mouse liver aggravates infection and pathology of the clinical strain BJ01. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes. LRP8 directly interacts with YFV 17D particles via the viral envelope protein. A soluble LRP8 decoy protein can block YFV 17D and BJ01 infection. Our findings provide insights for understanding YFV entry, tropism and pathogenesis.

Indexed as

LDL-Receptor Related ProteinsReceptors, VirusYellow FeverYellow fever virusAnimalsCell LineCulicidaeHepatocytesHumansLiverMiceViral Envelope ProteinsVirus InternalizationLDL-Receptor Related ProteinsReceptors, VirusViral Envelope Proteins

Identifiers

PMID41857414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.