ArticleNature plants2026
Stress drives plasticity in leaf ageing transcriptional dynamics in Arabidopsis thaliana.
Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Predicting transcriptional regulators in plants in the era of artificial intelligence.Current opinion in plant biology · 2026Review
- The C2H2-type zinc finger protein ZOS202 regulates leaf senescence in rice by targeting senescence-associated transcription factors and ROS homoeostasis.The Plant journal : for cell and molecular biology · 2026Article
- DNA methylation contributes to plant acclimation to naturally fluctuating light.The New phytologist · 2025Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Leaf development is dynamic, enabling plants to modulate their growth in response to environmental cues. Under drought conditions, for instance, the model plant Arabidopsis thaliana restricts leaf growth to conserve water, a strategy that enhances water-use efficiency. While this 'stress avoidance' response is well described physiologically, the underlying transcriptional changes that drive such developmental plasticity remain poorly understood. We investigated the transcriptional basis of how drought stress reshapes Arabidopsis leaf development. We profiled 1,226 leaves at various developmental stages and levels of drought stress, and generated a single-nucleus transcriptome atlas comprising ~1 million individual nuclei. We found that drought stress advances transcriptional programmes associated with leaf ageing in a dose-dependent manner, particularly within the mesophyll. These transcriptional shifts scale with stress intensity and correlate with reduced shoot growth, indicating that mesophyll-specific transcriptional changes underlie drought-induced restriction in leaf growth. Overexpression of FERRIC REDUCTION OXIDASE 6 (FRO6) in the mesophyll was sufficient to partially restore leaf growth under drought conditions. Our findings demonstrate how gene expression is reshaped by environmental cues to ensure that shoot architecture is adaptive to stress severity.
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