ArticleGeroScience2026
The role of modifiable risk factors on the cerebral myelin content and cognition: findings from The Maastricht Study.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Lifestyle-related factors may affect cognition and increase the risk of developing dementia. However, the neurobiological mechanisms underlying the effect of lifestyle-related factors on the brain are not yet fully understood. Myelin, a vital element of brain health, has previously been shown to be involved in dementia-related cognitive decline. However, whether it plays a role in the relation between lifestyle-related factors and cognitive performance has not been studied. The cerebral myelin content of 4653 participants (51% female, aged 59 ± 9 years) from The Maastricht Study was estimated using the T1w/FLAIR-ratio, and lifestyle-related factors were summarized using the LIBRA-score. Multivariable linear regression models, corrected for the effects of age, sex and education, were used to investigate whether lifestyle-related factors are associated with myelin. Moreover, whether myelin can partly explain the relationship between lifestyle-related factors and cognition was explored using a mediation analysis across three cognitive domains (memory, executive functioning and processing speed). An unhealthy lifestyle (i.e. higher LIBRA score) is significantly associated to a lower cerebral myelin content (β = -0.24, 95% CI [-0.26 -0.22], and p < 0.001). Furthermore, lower cerebral myelin content associates to worse cognitive performance (β = 0.14, 95% CI [0.11 0.17], and p < 0.001). Moreover, myelin has a partially mediating effect of 15%, indicating that it partly explains the relation between lifestyle-related factors and cognition. These results show that myelin content might help explain the mechanisms through which lifestyle-related factors influence cognition, potentially allowing for specific and early lifestyle interventions aimed at preventing or delaying cognitive decline and dementia.
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