ArticleScientific reports2026
Sex-biased plasma inflammatory protein profile in obesity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity-associated inflammation predisposes to cardiovascular disease (CVD). We investigated the association of biological sex with the plasma inflammatory protein profile in individuals with obesity. Clinical and proteomic data from 450 women and men with a body mass index (BMI) > 27 kg/m² without known CVD participating in the FAT associated CardiOvasculaR dysfunction study were analysed. The Olink Target 96 inflammation panel was employed in biobank samples. Hypertension was more prevalent among men, while age, BMI, and prevalences of obesity, diabetes and smoking did not differ between the sexes (all p > 0.05). In multivariable analyses, obesity was associated with downregulation of interleukin (IL) 7, IL 12 subunit beta, IL 6, and C-X-C motif chemokine 11, and upregulation of sulfotransferase 1A1 and SIR2-like protein 2 in women (all p < 0.05). In men, obesity was associated with downregulation of monocyte chemotactic protein 3, tumour necrosis factor superfamily member 12, IL 10 and protein S100-A12, and upregulation of neurotrophin-3 (all p < 0.05). In sum, the targeted protein profile in obesity differed by biological sex and there was no overlap in the differentially regulated proteins between women and men with obesity. The results suggest that pathophysiological mechanisms in obesity-associated inflammation and immune dysregulation may be sex-biased.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.