Evidence map›Paper›PMID 41857151›Full record

ReviewNature reviews. Chemistry2026

Enhancing chemical safety information for the future.

Peter A Reinhardt, Samuella B Sigmann, Leah R McEwen, Ellen M Cox, Grace Baysinger, Anna L Dunn, Kang Chen, Adelina Voutchkova-Kostal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter A ReinhardtEnvironmental Health & Safety, Yale University, Woodbridge, CT, USA. reinhardt1440@gmail.com.ORCID http://orcid.org/0009-0004-3143-4669
Samuella B SigmannIndependent researcher, Todd, NC, USA. sigmannsb@retired.appstate.edu.ORCID http://orcid.org/0000-0002-9705-2477
Leah R McEwenCornell University Library, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-2968-1674
Ellen M CoxDivision of Research and Innovation, Cornell University, Ithaca, NY, USA.
Grace BaysingerRobin Li and Melissa Ma Science Library, Stanford University Libraries (Emerita), San Jose, CA, USA.ORCID http://orcid.org/0000-0003-2570-9123
Anna L DunnProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0003-2852-7755
Kang ChenDepartment of Occupational Health and Safety, Capitol Technology University, Laurel, MD, USA.ORCID http://orcid.org/0000-0003-2569-227X
Adelina Voutchkova-KostalGreen Chemistry Institute, American Chemical Society, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safe manufacture, transport and use of chemicals - in short, the entire chemistry enterprise - depends on high-quality chemical safety information. That information must be accurate, audience-appropriate, comprehensive and based on data derived from research. The globally harmonized system of classification and labelling has standardized how chemical hazards are determined by manufacturers and then communicated to users through the use of labels and safety data sheets, but it has not been globally adopted. To lower risk to acceptable levels, users of chemicals rely on authoritative information to complete risk assessments. Safety data sheets are important tools, but they are merely a starting point for the risk assessment process - they can be insufficiently detailed, poorly curated and difficult to search. There is also an unrealistic expectation that users have the appropriate competencies to apply the information to risk-based safety principles such as RAMP (recognize hazards, assess risks, minimize risks and prepare for emergencies). The primary emphasis of this article is to raise awareness of persistent challenges with accessing and applying chemical safety information and to present a call to action for key stakeholders and expert groups to address these issues.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.