Evidence map›Paper›PMID 41857020›Full record

ArticleNPJ Parkinson's disease2026

Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model.

Laura Kondrataviciute, Minesh Kapadia, Ivan Skelin, Srdjan Sumarac, Luka Zivkovic, Luis Antonio Franco Vergara, Sabika Jafri, Cherisse Tan, Hien Chau, Yuhan Hou and 8 more

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Laura KondrataviciuteInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Minesh KapadiaKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Ivan SkelinKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Srdjan SumaracInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Luka ZivkovicInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Luis Antonio Franco VergaraInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Sabika JafriKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Cherisse TanKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Hien ChauKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Yuhan HouDepartment of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada.
Savanna BladeDepartment of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada.
Xilin LiuCRANIA, University Health Network and University of Toronto, Toronto, ON, Canada.
Clement HamaniDivision of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Taufik ValianteInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
William D HutchisonKrembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Luka Milosevic *Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada. Luka.Milosevic@mail.utoronto.ca.
Lorraine V Kalia *Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. Lorraine.Kalia@utoronto.ca.
Suneil K Kalia *Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. Suneil.Kalia@utoronto.ca.

Funding

Canadian Foundation for Innovation (CFI) Project 42608Canadian Institute for Health Research (CIHR) PJT 191880Natural Sciences and Engineering Council (NSERC) RGPIN-2022-05181
6 · The paper itself

Abstract

Parkinson's disease (PD) is a movement disorder characterized by alpha-synuclein (a-Syn) aggregation, dopaminergic degeneration, and pathological beta oscillations (13-30 Hz) in the basal ganglia circuit. Deep brain stimulation (DBS) is an effective neurosurgical treatment for the motor symptoms of PD. However, the extent to which mitigation of beta oscillations mediates DBS therapeutic effects remains uncertain. Using an adeno-associated virus-mediated nigral A53T a-Syn overexpression rat model, we examined basal ganglia-thalamo-cortical electrophysiology and the model's responsiveness to DBS. In vivo recordings revealed early beta emergence in the motor cortex (MCx), spreading to the subthalamic nucleus (STN) and entopeduncular nucleus (EP) with neurodegeneration. This was accompanied by alterations in STN and EP single-unit activity. Awake-state beta oscillations manifested as transient bursts. Low- and high-frequency DBS differentially modulated beta bursts and motor performance. Our results demonstrate that the A53T a-Syn model replicates key PD-like electrophysiological features, providing a platform to investigate DBS mechanisms and optimize therapies targeting aberrant beta activity.

Identifiers

PMID41857020
PMCPMC13153194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.