Evidence map›Paper›PMID 41856980›Full record

ArticleCell death & disease2026

NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling.

Aslihan Bastem Akan, Caroline V Billard, Szu-Ying Chen, Po-Hsien Huang, Patrizia Cammareri, Vidya Rajasekaran, Adam E Hall, Paula Preyzner, Sebastian Öther-Gee Pohl, Susan M Farrington and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aslihan Bastem AkanInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Caroline V BillardInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4953-353X
Szu-Ying ChenInstitute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.ORCID http://orcid.org/0000-0002-3998-5922
Po-Hsien HuangInstitute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.ORCID http://orcid.org/0000-0002-2997-5181
Patrizia CammareriInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Vidya RajasekaranInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Adam E HallInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Paula PreyznerInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Sebastian Öther-Gee PohlInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4294-9498
Susan M FarringtonInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Malcolm G DunlopInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Farhat V N DinInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.
Kevin B MyantInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK. kevin.myant@ed.ac.uk.ORCID http://orcid.org/0000-0001-8017-1093

Funding

Cancer Research UK (CRUK) A19166EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 715782RCUK | Medical Research Council (MRC) MR/X008762/1
6 · The paper itself

Abstract

Colorectal cancer is initiated by loss of APC, which drives expansion of LGR5+ intestinal stem cell (ISC) populations. Whilst LGR5 + ISC expansion is a critical step for tumour initiation and progression, its regulation is poorly understood. Emerging evidence suggests post-transcriptional RNA modifications play a key role in cancer biology, but their role in CRC initiation has not been explored. Here, we identify the m

Indexed as

Colorectal NeoplasmsIntestinesMAP Kinase Signaling SystemMethyltransferasesStem CellsAnimalsCarcinogenesisCell ProliferationEpitranscriptomeHumansMiceRNA MethylationMethyltransferasesNSUN2 protein, human

Identifiers

PMID41856980
PMCPMC13039175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.