Evidence map›Paper›PMID 41856961›Full record

ArticleGut microbes2026

Discovery of a secreted

Yoshiki Narimatsu, Cayetano Pleguezuelos-Manzano, Daniel Hornikx, Felix Goerdeler, Thapakorn Jaroentomeechai, Katia Flores, Sanae Narimatsu, Charelle Boot, Lars Hansen, Fabien Durbesson and 9 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yoshiki NarimatsuDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1428-5695
Cayetano Pleguezuelos-ManzanoHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.ORCID 0000-0003-4676-9838
Daniel HornikxDepartment of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0001-6013-800X
Felix GoerdelerDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7190-9145
Thapakorn JaroentomeechaiDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Katia FloresDepartment of Microbiology, Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Sanae NarimatsuDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Charelle BootHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Lars HansenDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Fabien DurbessonArchitecture et Fonction des Macromolecules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille University, Marseille, France.
Renaud VincentelliArchitecture et Fonction des Macromolecules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille University, Marseille, France.ORCID 0000-0001-9667-0196
Laurie ComstockDepartment of Microbiology, Duchossois Family Institute, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9298-9973
Hans CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-3077-5582
Victor TalebThe Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Zaragoza, Spain.ORCID 0000-0001-9224-5854
Francisco CorzanaDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Logroño, Spain.ORCID 0000-0001-5597-8127
Bernard HenrissatArchitecture et Fonction des Macromolecules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille University, Marseille, France.ORCID 0000-0002-3434-8588
Henrik ClausenDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0915-5055
Ramon Hurtado-GuerreroDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3122-9401
Christian BüllDepartments of Cellular and Molecular Medicine, Copenhagen Center for Glycomics & Center for Glycocalyx Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7785-2920

Funding

Secreted antimicrobial proteins of the intestinal BacteriodalesR01AI093771 · NIAID · UNIVERSITY OF CHICAGO · PI LAURIE E COMSTOCK · 2012 to 2026
$5.1M
NIAID NIH HHS R01 AI093771
6 · The paper itself

Abstract

Degradation of mucins at the host-microbial mucus interphase involves glycosidases that release monosaccharides from O-glycans and mucinases that cleave the mucin protein backbone. Mucinases recognize and cleave peptide bonds at specific sequence motifs with varying O-glycan structures required and/or permissible. Mucinases that digest mucins with intact O-glycans can potentially destroy the protective mucus, while mucinases that only digest mucins with partially degraded O-glycans may serve at a later stage of nutrient sourcing from mucins. Here, we discovered nine CBM-bearing M60-like mucinases across gut commensals and opportunists, including a conserved

Indexed as

Bacteroides fragilisMucinsPolysaccharidesCarbohydrate Binding ModulesHumansSubstrate SpecificityMucinsPolysaccharidesbacteroidesM60-like peptidasesmicrobiomeMucinasemucinsO-glycans

Identifiers

PMID41856961
PMCPMC13003899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.