Evidence map›Paper›PMID 41856808›Full record

ReviewTrends in biotechnology2026

Revolutionizing vision using corneal 3D printing.

Bowen Zhang, F A Dain Md Opo, Daniel Nahra, James Chodosh, Miguel Gonzalez-Andrades, Mohammad Mirazul Islam, Hirak K Patra

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bowen ZhangDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, London NW3 2PF, UK; School of Mechanical Engineering, State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China.
F A Dain Md OpoDepartment of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM 87106, USA.
Daniel NahraHospital del Mar, Ciutat Vella, Barcelona 08003, Spain.
James ChodoshDepartment of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM 87106, USA.
Miguel Gonzalez-AndradesMaimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, Cordoba 14004, Spain.
Mohammad Mirazul IslamDepartment of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM 87106, USA.
Hirak K PatraDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, London NW3 2PF, UK. Electronic address: hirak.patra@ucl.ac.uk.

Funding

Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
Novel Mechanisms in Adenoviral Ocular PathogenesisR01EY021558 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI James Chodosh, Jaya Rajaiya · 2011 to 2026
$7.1M
Mesenchymal Stem Cells can Restore and Maintain Corneal Endothelial FunctionR00EY031373 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Mohammad Mirazul Islam · 2024 to 2026
$746k
NEI NIH HHS R00 EY031373NEI NIH HHS R01 EY013124NEI NIH HHS R01 EY021558
6 · The paper itself

Abstract

Corneal diseases remain a leading cause of blindness, and corneal transplantation is the primary treatment for severe cases. However, the persistent shortage of donor corneas significantly limits this approach. Artificial corneas with engineered biomaterials designed to mimic the structure and function of native corneal tissue offer a promising alternative, and significant progress has been made, including FDA approval and clinical trials. Among emerging technologies, 3D printing enables personalized customization of implants tailored to patient needs, anatomy, and pathology. This method also enables precise control over the biomaterial composition and integration of living cells within the implant, enhancing post-transplantation regeneration. In this review, we examine the advancements in 3D-printed, proregenerative artificial corneas, focusing on innovative biofabrication and the challenges that remain in ensuring implant quality.

Indexed as

3D bioprintingartificial corneacorneal scaffoldcorneal transplantationproregenerative artificial cornea

Identifiers

PMID41856808
PMCPMC13570457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.