ArticleBMJ (Clinical research ed.)2026
Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study.
Article in BMJ (Clinical research ed.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Abdominal Obesity and Kidney Function Among Middle-Aged and Older Adults With Normal Body Mass Index.Kidney medicine · 2026Article
- Use of Cystatin C in Tandem with Creatinine to Improve GFR Estimation and Clinical Decision Making.Journal of the American Society of Nephrology : JASN · 2026Review
- Impact of Equation Choice on Models Assessing the Association Between Lipoprotein(a) and Estimated Glomerular Filtration Rate in Adult Patients Without Chronic Kidney Disease.Diseases (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo provide evidence on the longitudinal accuracy of glomerular filtration rate (GFR) estimating equations that include creatinine and cystatin C to monitor patients with moderate chronic kidney disease.
designProspective, longitudinal, cohort study.
settingPrimary, secondary, and tertiary care across six centres in England, 1 April 2014 to 31 December 2017.
participants1229 adults (≥18 years) with moderate chronic kidney disease (creatinine estimated GFR of 30-59 mL/min/1.73 m
main outcome measuresAbility of estimating equations to monitor GFR over three years, with slope deviations from reference measured GFR (iohexol clearance) within ±3 mL/min/1.73 m
resultsAfter three years, 875 participants had measured and estimated GFR data recorded at the start and end of the study and comprised the study cohort. Median measured GFR decreased from 48.1 mL/min/1.73 m
conclusionsUnderestimation of the reduction in GFR by estimated GFR requires further investigation. Equations that included both creatinine and cystatin C more accurately monitored change in measured GFR than equations based on one biomarker. Increased use of combined biomarker equations in clinical practice could improve disease monitoring and potentially clinical care. STUDY REGISTRATION: ISRCTN registry ISRCTN42955626.
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