Evidence map›Paper›PMID 41856379›Full record

ArticleVirus research2026

Virome of the fungi associated with mushroom dry bubble disease.

Lóránt Hatvani, Sakae Hisano, Hideki Kondo, Hitomi Sugahara, Paul Telengech, Sabitree Shahi, Sarah Remi Ibiang, Sándor Kocsubé, Tünde Kartali, David A Fitzpatrick and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lóránt HatvaniTeagasc Food Research Center, Horticulture Development Department, Ashtown, Dublin 15, D15KN3K, Ireland; Institute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Sakae HisanoInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Hideki KondoInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Hitomi SugaharaInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Paul TelengechInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Sabitree ShahiInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Sarah Remi IbiangInstitute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan.
Sándor KocsubéDepartment of Biotechnology and Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Közép fasor 52., H-6726, Hungary.
Tünde KartaliDepartment of Biotechnology and Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Közép fasor 52., H-6726, Hungary.
David A FitzpatrickGenome Evolution Laboratory, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.
Helen GroganTeagasc Food Research Center, Horticulture Development Department, Ashtown, Dublin 15, D15KN3K, Ireland. Electronic address: helen.grogan16@gmail.com.
Nobuhiro SuzukiTeagasc Food Research Center, Horticulture Development Department, Ashtown, Dublin 15, D15KN3K, Ireland; Institute of Plant Science and Resources, Okayama University, Chuou 2-20-1, Kurashiki, Okayama 710-0046, Japan; Neovirology Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. Electronic address: nsuzuki@okayama-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry bubble disease, attributed to the filamentous fungus Lecanicillium fungicola (Cordycipitaceae) results in huge yield losses in mushroom (Agaricus bisporus) cultivation worldwide. The possibilities for controlling the disease using commercial fungicides are highly limited, and therefore, there is an increasing demand for novel, alternative means of pest management. Our research objective was the comprehensive examination of viruses in the causal agents of dry bubble disease, which may open up an avenue for its virocontrol in the future. Out of 57 fungal isolates obtained from dry bubble-affected A. bisporus crops in various countries, 47 (82%) were confirmed by ITS (Internal Transcribed Spacer) sequence analysis as L. fungicola. In addition, different members of the genera Akanthomyces and Simplicillium (7 and 3 isolates, respectively), yet unknown to cause dry bubble symptoms, have also been detected. Cellulose column chromatography revealed the presence of double-stranded (ds) RNA in seven L. fungicola and three Akanthomyces sp. isolates, suggesting viral infection. The ten dsRNA-positive and eight randomly selected dsRNA-negative fungal strains were subjected to rRNA-depletion high-throughput RNA-sequencing analysis. The presence of seven new viruses representing four new species in the established families, Partitiviridae, Polymycoviridae, Botourmiaviridae and the narna-like virus group, and three previously established/proposed species in the families Chrysoviridae and "Mycovirgaviridae" were confirmed. The impact of the detected and identified viruses on their host fungi, and their potential applicability for virocontrol purposes will be examined in the future. This study provides the first detailed report on viruses of mushroom pathogenic fungi.

Indexed as

AgaricusFungal VirusesHypocrealesViromeHigh-Throughput Nucleotide SequencingPhylogenyRNA, Double-StrandedRNA, ViralRNA, Double-StrandedRNA, ViralAgaricus bisporusAkanthomycesBotourmiaviridaedsRNAFungal virusLecanicillium fungicolaMycovirgaviridaeMyovirusNarna-like virusPartitiviridaePolymycoviridaeSimplicilliumSplipalmiviridae

Identifiers

PMID41856379
PMCPMC13068599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.