ArticleAnimal bioscience2026
Association analysis and in silico functional predictions of RMDN2 variants in chickens.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveMicrotubule dynamics regulator protein 2 (RMDN2) plays a crucial role in cell division, cytoskeleton maintenance, and various cellular processes, thereby establishing it as a candidate gene influencing chicken follicle development in our previous studies. This research aims to explore single-nucleotide polymorphisms (SNPs), perform phylogenetic analysis, and assess sequence characteristics of RMDN2, offering valuable insights for molecular marker-assisted breeding and enhancing the understanding of its regulatory mechanisms.
methodsSNPs within the RMDN2 coding sequence region were identified in an F2 resource population. Bioinformatics tools were employed to investigate the effects of SNP mutations on the structure and function of RMDN2 protein. Additionally, a phylogenetic tree was constructed to elucidate the potential mechanisms underlying the role of RMDN2 in chicken laying traits.
resultsFour novel exonic SNPs were identified: SNP1 (c.250G>A, p.Val84Ile), SNP2 (c.270G>C, p.Lys90Asn), SNP3 (c.533G>T, p.Gly178Val), and SNP4 (c.606G>A). The heterozygous genotypes of SNP1, SNP3, and SNP4 showed a significant association with increased egg number at 66 weeks (p<0.05). In contrast, the heterozygous genotype of SNP2 is associated with higher body weight at first egg (BWFE) (p<0.05). Notably, the H1H1 haplotype combination demonstrated a significant association with reduced BWFE, body weight at 105 days, and first egg weight (p<0.05). Missense mutations in SNP1, SNP2, and SNP3 may influence the hydrophilic/hydrophobic properties, transmembrane regions, functional domains, and secondary structure of the RMDN2 protein, potentially reducing its stability. Phylogenetic analysis demonstrated complete sequence homology between chicken and quail, indicating substantial conservation within species of the same order, while showing a marked decrease across different taxonomic orders.
conclusionThese findings enrich the candidate gene pool associated with the regulation of laying traits in chickens. However, further validation through in vivo and in vitro experiments remains necessary to strengthen the theoretical foundation for molecular breeding strategies.
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