ArticleDrug metabolism and disposition: the biological fate of chemicals2026
Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Insights from k
Article in Drug metabolism and disposition: the biological fate of chemicals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Prediction of human intestinal metabolism within physiologically based pharmacokinetic models is now well established within drug development. Extrapolation of in vitro kinetic parameters accounts for differences in abundance between different in vitro systems and tissues. The existing data assume that the activity of CYP3A4 is consistent between the intestine and liver once adjusted for its tissue-specific expression level. However, the validity of this assumption for other enzymes and other tissues remains uncertain. In the current study, indicators of "activity per unit of enzyme," namely, turnover number (k
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