Evidence map›Paper›PMID 41855450›Full record

Observational studyNeurology2026

Striatal Dopamine Transporter and Rest Tremor in Parkinson Disease: A Clinical Validation.

Kalle J Niemi, Elina Jaakkola, Elina Maaria Myller, Mikael R E Eklund, Simo Nuuttila, Tuomas Mertsalmi, Kirsi-Marja Murtomäki, Reeta Levo, Tommi Noponen, Toni Ihalainen and 3 more

Erratum issuedAbstract readObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kalle J NiemiTurku Brain and Mind Center, University of Turku, Finland.ORCID 0000-0003-3960-0815
Elina JaakkolaTurku Brain and Mind Center, University of Turku, Finland.
Elina Maaria MyllerTurku Brain and Mind Center, University of Turku, Finland.ORCID 0000-0001-7591-1990
Mikael R E EklundTurku Brain and Mind Center, University of Turku, Finland.
Simo NuuttilaClinical Neurosciences, University of Turku, Finland.
Tuomas MertsalmiDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Finland.
Kirsi-Marja MurtomäkiDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Finland.ORCID 0000-0001-5759-1911
Reeta LevoDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Finland.ORCID 0000-0003-4481-1254
Tommi NoponenDepartment of Clinical Physiology, Nuclear Medicine, Turku PET Centre and Medical Physics, Turku University Hospital and Wellbeing Services County of Southwest Finland.ORCID 0000-0003-0748-8822
Toni IhalainenDepartment of Clinical Physiology and Nuclear Medicine, Helsinki University Hospital and University of Helsinki, Finland; and.ORCID 0009-0000-6698-9817
Filip ScheperjansDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Finland.ORCID 0000-0001-9502-7131
Juho JoutsaTurku Brain and Mind Center, University of Turku, Finland.ORCID 0000-0002-3457-9415
Valtteri KaasinenClinical Neurosciences, University of Turku, Finland.ORCID 0000-0002-3446-7093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe mechanisms underlying tremor generation in Parkinson disease (PD) remain unclear. Previously, we demonstrated a connection between rest tremor amplitude and higher dopamine transporter (DAT) binding in the ipsilateral striatum among the Parkinson Progression Markers Initiative cohort. Here, we investigated the association of parkinsonian motor symptoms with striatal DAT binding in a sizable and clinically representative sample of patients with parkinsonian signs to validate the previously observed ipsilateral relationship in PD.

methodsThis observational cross-sectional study included right-handed patients referred for [

resultsAt the end of the follow-up period, of the 414 patients included (median age 68 years [IQR 14], 49.4% female), 148 were evaluated to have PD and 79 other forms of parkinsonism with striatal DAT deficit. In total, 187 patients had normal binding. Among the patients with PD, left and right rest tremor amplitudes were positively associated with ipsilateral striatal DAT binding (β = +0.12 [95% CI +0.05, +0.19] and +0.10 [+0.05, +0.15] specific binding ratio [SBR] per point; DISCUSSION: These findings confirm the positive association between rest tremor amplitude and ipsilateral striatal DAT binding in a clinical sample of PD patients. However, the non-PD groups were diagnostically heterogeneous, limiting conclusions about disease specificity.

Indexed as

Corpus StriatumDopamine Plasma Membrane Transport ProteinsParkinson DiseaseTremorAgedCross-Sectional StudiesDopaminergic ImagingFemaleHumansMaleMiddle AgedTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamine Plasma Membrane Transport ProteinsTropanes

Identifiers

PMID41855450
PMCPMC13035098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.