Evidence map›Paper›PMID 41855445›Full record

ArticlePloS one2026

Modeling and benchmarking quantum optical neurons for efficient neural computation.

Andrea Andrisani, Gennaro Vessio, Fabrizio Sgobba, Francesco Di Lena, Luigi Amato Santamaria, Giovanna Castellano

Abstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea AndrisaniGiuseppe Colombo Centre for Space Geodesy, Italian Space Agency, Matera, Italy.
Gennaro VessioDepartment of Computer Science, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0002-0883-2691
Fabrizio SgobbaDepartment of Physics, University of Bari Aldo Moro, Bari, Italy.
Francesco Di LenaGiuseppe Colombo Centre for Space Geodesy, Italian Space Agency, Matera, Italy.
Luigi Amato SantamariaGiuseppe Colombo Centre for Space Geodesy, Italian Space Agency, Matera, Italy.
Giovanna CastellanoDepartment of Computer Science, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0002-6489-8628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantum optical neurons (QONs) are emerging as promising computational units that leverage photonic interference to perform neural operations in an energy-efficient and physically grounded manner. Building on recent theoretical proposals, we introduce a family of QON architectures based on Hong-Ou-Mandel (HOM) and Mach-Zehnder (MZ) interferometers, incorporating different photon modulation strategies-phase, amplitude, and intensity. These physical setups yield distinct pre-activation functions, which we implement as fully differentiable software modules. We evaluate these QONs both in isolation and as building blocks of multilayer networks, training them on binary and multiclass image classification tasks using the MNIST and FashionMNIST datasets. Each experiment is repeated over five independent runs and assessed under both ideal and non-ideal conditions to measure accuracy, convergence, and robustness. Across settings, MZ-based neurons exhibit consistently stable behavior-including under noise-while HOM amplitude modulation performs competitively in deeper architectures, in several cases approaching classical performance. In contrast, phase- and intensity-modulated HOM-based variants show reduced stability and greater sensitivity to perturbations. These results highlight the potential of QONs as efficient and scalable components for future quantum-inspired neural architectures and hybrid photonic-electronic systems. The code is publicly available at https://github.com/gvessio/quantum-optical-neurons.

Indexed as

Neural Networks, ComputerNeuronsBenchmarkingQuantum Theory

Identifiers

PMID41855445
PMCPMC13002181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.