Evidence map›Paper›PMID 41855397›Full record

ArticleThe Journal of organic chemistry2026

Synthesis and Antiproliferative Activity of Fluorinated

Aleš Krčil, Lucia Šutvajová, Vojtěch Hamala, Ivana Císařová, Martin Kurfiřt, Lucie Červenková Št'astná, Jana Bernášková, Roman Hrstka, Jindřich Karban

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Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aleš KrčilInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.
Lucia ŠutvajováDepartment of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Vojtěch HamalaInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.ORCID 0000-0003-1262-2344
Ivana CísařováDepartment of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 8, CZ-128 43 Praha 2, Czech Republic.ORCID 0000-0002-9612-9831
Martin KurfiřtInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.ORCID 0000-0002-3040-8467
Lucie Červenková Št'astnáInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.ORCID 0000-0002-9968-1082
Jana BernáškováInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.
Roman HrstkaResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Žlutý Kopec 7, 656 53 Brno, Czech Republic.ORCID 0000-0002-6139-2664
Jindřich KarbanInstitute of Chemical Process Fundamentals of the CAS, V. V. I., Rozvojová 1/135, 165 00 Praha, Czech Republic.ORCID 0000-0001-5360-1035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introducing fluorine into monosaccharides, or their incomplete acylation that leaves the anomeric group unprotected, can impart antitumor properties to the resulting glycomimetics. This property could be exploited in the development of new antiproliferative agents. Herein, we report the synthesis and antiproliferative activity of a complete series of deoxyfluorinated analogs of acylated

Indexed as

Antineoplastic AgentsHexosaminesCell CycleCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHalogenationHumansMDA-MB-231 CellsMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsHexosaminesN-acetylmannosamine

Identifiers

PMID41855397
PMCPMC13054866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.