Evidence map›Paper›PMID 41855230›Full record

ArticleJournal of agricultural and food chemistry2026

Validating Direct Mass Spectrometry Screening for Grease-Proofers Containing 6:2 Fluorotelomer Alcohol in Fiber-Based Food Packaging.

Luke K Ackerman, Peter F Scholl, Clark D Ridge, Jennifer Janovick, Iris Yourick, Victoria Anderson, Ann M Knolhoff, Katherine Carlos

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luke K AckermanUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.
Peter F SchollUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.
Clark D RidgeUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.ORCID 0000-0002-0718-2543
Jennifer JanovickJoint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, Maryland 20742, United States.
Iris YourickUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.
Victoria AndersonUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.
Ann M KnolhoffUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.ORCID 0000-0002-9733-7640
Katherine CarlosUS-Food and Drug Administration (FDA) Human Foods Program, College Park, Maryland 20740, United States.

Funding

FDA HHS U01 FD001418
6 · The paper itself

Abstract

Recently, polymeric PFAS-containing grease-proofers were removed from the U.S. food contact market. Validated methods are needed to monitor the removal of polymeric grease-proofers containing 6:2-fluorotelomer alcohol (6:2-FTOH) from fiber-based food packaging. Small-molecule extraction methods are neither specific nor rapid enough to screen for the intentional use of polymers. Direct analysis in real time mass spectrometry (DART-MS) approaches have shown promise for screening polymeric grease-proofers containing 6:2-FTOH but require method validation for regulatory implementation. A hydrolysis isotope dilution DART-MS (ID-DART-MS) method was refined to meet the FDA compound identification and validation guidelines. Method validation experiments demonstrated that hydrolyzable 6:2-FTOH from grease-proofers was identified across all fiber-based food packaging types with less than 5% false positive or negative rates (95% confidence) and a linear response across 4 μg/kg-130 mg/kg hydrolyzed 6:2-FTOH. The method reliably identified six different fluorotelomer-containing grease-proofers with 14 min/sample of effort, making it fit to assess incidence and removal of these PFAS-based grease-proofers.

Indexed as

FluorocarbonsFood ContaminationFood PackagingMass SpectrometryDietary FiberDietary FiberFluorocarbonsDART-MSintentional usepaperPFAS

Identifiers

PMID41855230
PMCPMC13112323

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.