Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2026
Acute cocoa ingestion decreases spontaneous cardiac baroreflex sensitivity in healthy older adults.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Prior reports suggested the beneficial effects of cocoa intake on cardiovascular system. However, the effects of cocoa on cardiac baroreflex sensitivity (CBRS) remain poorly understood. In this study, we hypothesized that cocoa ingestion would increase CBRS in a dose-dependent manner. Seventeen healthy older adults (61 ± 8 yr; 8 M, 9 F) participated in five trials using 250-mL drinks containing 0, 2, 5, 13, or 26 g of cocoa, whereas the drinks had a similar appearance and taste. The trials were conducted in a randomized, double-blind design, at the same time each morning, with at least 72 h between sessions. Two hours after ingesting the experimental drink, beat-by-beat heart rate (HR) and blood pressure (BP) were recorded in a supine position. Spontaneous CBRS was calculated from the beat-by-beat systolic BP and RR interval data using a sequence method. There were no significant differences in BP and HR after ingesting the drink across all visits (repeated-measures ANOVA;
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