ArticleJournal of immunotherapy (Hagerstown, Md. : 1997)
Immune-Related Adverse Events Among Patients With Endometrial Cancer Receiving Pembrolizumab Alone or With Other Treatments: A Single-Center Real-World Experience.
Article in Journal of immunotherapy (Hagerstown, Md. : 1997). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunotherapy has revolutionized endometrial cancer (EC) treatment; our objectives were to characterize immune-related adverse events (irAE) among EC patients and to identify factors associated with risk for irAE. Patients who received pembrolizumab alone or as part of combination therapy for advanced/recurrent EC from 2014 to 2025 were identified. Baseline demographics and cancer characteristics were collected. Potential immune-related adverse events were collected and graded for the cohort. Multiple logistic regression was then performed. A total of 180 patients were included. The mean age was 63.9 years. Black patients comprised 30.6% of the cohort. Endometrioid was the commonest histologic subtype (38.7%), and most tumors (67.7%) were MMR proficient. Ninety-five patients (52.8%) had any-grade irAE, and 14 (7.8%) experienced serious (grades 3-4) irAE. Hypothyroidism was the most common irAE overall (n = 37; 20.6%,) followed by fatigue (n = 23; 12.8%) and diarrhea (n = 20; 11.1%). The most common serious irAEs were diarrhea (n = 4; 2.2%,) followed by hepatitis, dermatitis, and pneumonitis (each n = 3; 1.7%). On univariate analysis, older age, uninsured status, and receipt of pembrolizumab with lenvatinib were associated with any-grade irAE (all P <0.05). In our multiple logistic regression model, uninsured status was an independent predictor of both any-grade irAE (aOR: 5.49; 95% CI: 1.03-29.2) and serious irAE (aOR: 7.96; 95% CI: 1.44-43.9). Receiving pembrolizumab with lenvatinib was independently associated with any-grade irAE (aOR: 7.13; 95% CI: 2.92-17.4). Uninsured status and coadministration with lenvatinib may increase the risk for pembrolizumab-associated irAE among patients with EC. Further collection of real-world data, including unexplored social and economic factors and novel biomarkers, may predict irAE and ultimately help guide clinical decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.