ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026
Altered lung function in mice is a sensitive indicator of lung damage following 6 months of electronic nicotine delivery system aerosol exposure.
Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
With the rising prevalence of vaping, there is a pressing need to identify biomarkers of toxicity related to chronic effects induced by the inhalation of electronic nicotine delivery system (ENDS) aerosols. In a mouse model, we investigated the long-term pulmonary effects associated with exposures to cinnamon-flavored ENDS aerosols for up to 6 mo. Following exposures and after 2 mo of recovery, pulmonary function testing and lung biochemical responses were assessed. Despite similar serum cotinine concentrations in male and female mice, males exposed for 6 mo to ENDS aerosols exhibited significant reductions in tidal and minute volumes, breathing frequency, and elevated respiratory elastance, while significantly increased tissue damping and respiratory resistance were observed in both sexes. All parameters, except minute volume and breathing frequency in males, returned to baseline following recovery. Although there were no significant changes in pulmonary inflammation in all groups, lung RNA sequencing revealed significant upregulation of
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