ArticleFEBS open bio2026
Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short-term immobilization.
Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
Disuse-induced muscle atrophy may involve dysregulated iron metabolism, yet the underlying mechanisms are unclear. We examined iron homeostasis in mouse gastrocnemius muscle following 14-day casting-induced immobilization. Muscle mass declined by ~ 25%, accompanied by increased nonheme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated, suggesting disruption of IRP/IRE feedback control. Additionally, levels of 4-hydroxynonenal, a marker of lipid peroxidation, were elevated without compensatory responses from SLC7A11/xCT or GPx4. These findings indicate that short-term immobilization disrupts iron regulatory mechanisms and induces oxidative stress exceeding antioxidant capacity. Iron dysregulation and lipid peroxidation may contribute to the early pathogenesis of disuse-induced muscle atrophy and represent potential therapeutic targets.
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