Evidence map›Paper›PMID 41854912›Full record

Observational studyInternational ophthalmology2026

Argon laser demarcation of AIDS-related cytomegalovirus retinitis in resource-limited setting.

Lynn M Hassman, Khin Thida Oo, Zaw Minn Din, Marissa Larochelle, NiNi Tun, Ronald Hobbs, Christian Concepcion, Gary Holland, David Heiden, Albert T Vitale

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lynn M HassmanDepartment of Ophthalmology and John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, Utah, 84132, USA. lynn.hassman@cuanschutz.edu.ORCID http://orcid.org/0000-0001-9939-9071
Khin Thida OoMyanmar Eye Centre, Pun Hlaing Hospital, Pun Hlaing Golf Estate, Hlaing Thar Yar Township, Yangon, Myanmar.
Zaw Minn DinMyanmar Eye Centre, Pun Hlaing Hospital, Pun Hlaing Golf Estate, Hlaing Thar Yar Township, Yangon, Myanmar.
Marissa LarochelleDepartment of Ophthalmology and John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, Utah, 84132, USA.
NiNi TunMedical Action Myanmar, Yangon, Myanmar.
Ronald HobbsDepartment of Ophthalmology and John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, Utah, 84132, USA.
Christian ConcepcionDepartment of Ophthalmology and Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Denver, CO, USA.
Gary HollandOcular Inflammatory Disease Center, Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
David HeidenSeva Foundation, Berkeley, CA, USA.
Albert T VitaleDepartment of Ophthalmology and John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, Utah, 84132, USA. Albert.Vitale@hsc.utah.edu.

Funding

Resolution of ocular inflammation: the role of type 1 conventional dendritic cellsK08EY033045 · NEI · WASHINGTON UNIVERSITY · PI Lynn M Hassman · 2022 to 2026
$1.1M
NEI NIH HHS K08 EY033045
6 · The paper itself

Abstract

purposeWe evaluated outcomes associated with argon laser demarcation of cytomegalovirus (CMV) retinitis lesions to prevent retinal detachments amongst people with AIDS in a resource-poor setting.

methodsWe performed a retrospective, longitudinal, observational cohort study of patients with AIDS-related CMV retinitis who were treated with laser demarcation to prevent retinal detachment during a 4-year period at a single facility in Yangon, Myanmar. The main outcomes were retinal detachment and loss of central visual acuity. We also evaluated a comparator group of patients who presented with AIDS-related CMV retinitis and concomitant retinal detachment.

resultsLaser demarcation was performed on 45 eyes (38 patients). All were receiving combination antiretroviral therapy (cART). All treated eyes had inactive CMV retinitis lesions involving ≥ 25% of the retinal area. No eye developed a retinal detachment or loss of central visual acuity during follow-up for 3 years. In contrast, eyes that presented with retinal detachments that were surgically repaired experienced further loss of vision (6 of 14 eyes [42%]) and recurrent detachments (4 of 14 eyes [28.6%]).

conclusionsAlthough laser demarcation of CMV retinitis lesions is not routinely performed in geographic regions where patients can be followed closely and have access to vitreoretinal surgeons, the procedure may be useful for some patients in resource-limited settings.

Indexed as

AIDS-Related Opportunistic InfectionsCytomegalovirus RetinitisEye Infections, ViralLaser CoagulationRetinal DetachmentAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedResource-Limited SettingsRetrospective StudiesVisual AcuityAIDSBarrier laserCytomegalovirus retinitisResource poor settingRetinal detachment

Identifiers

PMID41854912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.