Evidence map›Paper›PMID 41854854›Full record

ArticleApplied biochemistry and biotechnology2026

Internal Heat Acupuncture Treatment Inhibits Ferroptosis in the Spinal Dorsal Horn in Neurotoxin-Induced Parkinson's Disease Rats.

Zhenbao Gan, Wanglong Chen, Yanan Ma, Wenjing Jiang, Zhipei Zhong, Zhijiang He, Xiongjiang Wang

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhenbao Gan *Department of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China.
Wanglong Chen *Department of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China.
Yanan MaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China.
Wenjing JiangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China.
Zhipei ZhongDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China.
Zhijiang HeDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, 327 Xianhu Avenue, Qingxiu District, Nanning, 530023, China. 570266203@qq.com.
Xiongjiang WangGraduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, 13 Wuhe Avenue, Qingxiu District, Nanning, 530023, China. wangxj@gxtcmu.edu.cn.

Funding

Study on the mechanism of Zhuangyi meridian massage for anti-inflammatory and analgesic effects based on GSK3 β/Nrf2/GPX4 pathway regulation of iron death in spinal dorsal horn neurons of NPP rats 82460980
6 · The paper itself

Abstract

Parkinson’s disease (PD) is the second neurodegenerative disorder with limited therapeutic options. Ferroptosis is involved in the pathogenesis of PD. This study aimed to investigate the neuroprotective effects of internal heat acupuncture (IHA) in a PD model, focusing on its impact on ferroptosis. A neurotoxin-induced PD rat model was established using 6-hydroxydopamine (6-OHDA). These rats received IHA therapy. Behavioral tests were conducted to assess motor function and neuropathic pain. Serum inflammatory cytokines were evaluated by enzyme-linked immunosorbent assay. Ferroptosis markers and the role of the GSK3β/Nrf2/GPX4 pathway were measured by western blot. The results showed that IHA enhanced motor function, attenuated pain hypersensitivity, and suppressed systemic inflammation in PD rats. Concurrently, IHA inhibited ferroptosis in the spinal dorsal horn of PD rats, evidenced by decreased lipid peroxidation and iron accumulation, restored antioxidant capacity, and downregulated ferroptosis- and ferritinophagy-related markers. In addition, IHA decreased GSK3β expression and upregulated the Nrf2 and GPX4 expression, and overexpression of GSK3β reversed the effect on PD rats induced by IHA. In conclusion, IHA treatment suppresses ferroptosis in the spinal dorsal horn by targeting the GSK3β/Nrf2/GPX4 pathway, thereby alleviating PD-induced motion disorders, neuropathic pain, and inflammation. These findings suggest that IHA may be an effective approach to treating PD and reveal a mechanism of its action.

Indexed as

Acupuncture TherapyFerroptosisHot TemperatureNeurotoxinsParkinson DiseaseSpinal Cord Dorsal HornAnimalsDisease Models, AnimalGlycogen Synthase Kinase 3 betaMaleNF-E2-Related Factor 2OxidopaminePhospholipid Hydroperoxide Glutathione PeroxidaseRatsRats, Sprague-DawleyGlycogen Synthase Kinase 3 betaGsk3b protein, ratNeurotoxinsNfe2l2 protein, ratNF-E2-Related Factor 2OxidopaminePhospholipid Hydroperoxide Glutathione PeroxidaseFerroptosisGSK3β/Nrf2/GPX4 pathwayInternal heat acupuncture therapyParkinson's diseaseSpinal dorsal horn

Identifiers

PMID41854854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.