Evidence map›Paper›PMID 41854795›Full record

ArticleDiscover oncology2026

The correlation between telomere length of the peripheral blood basophil and the risk and prognosis of hepatocellular carcinoma.

Yongzhi Liu, Yang Chen, Zhidong Fu, Lihui Jiang, Feng Jiang, Chuanling Zhang, Tieming Zhu

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Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yongzhi Liu *Department of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China.
Yang Chen *Department of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China.
Zhidong FuDepartment of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China.
Lihui JiangDepartment of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China.
Feng JiangDepartment of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China.
Chuanling ZhangDepartment of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China. zhangchuanling@hznu.edu.cn.
Tieming ZhuDepartment of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728, Yucai North Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China. zhu_tieming@163.com.

Funding

Hangzhou Science and Technology Development Plan Project 20211231Y119Zhejiang Province Medical and Health Science and Technology Plan Project 2022KY1059
6 · The paper itself

Abstract

introductionThe role of peripheral blood basophil (PBB) and their telomere length (TL) in the pathogenesis and prognosis of hepatocellular carcinoma (HCC) patients has not been fully studied. The correlation between PBB and TL is the risk of HCC.

methods30 healthy participants and 80 HCC patients from our hospital were included in this study, and their clinical baseline data and clinical characteristics were statistically analyzed. TL and telomerase in PBB were analyzed using quantitative real-time PCR. Univariate and multivariate Cox regression, Kaplan-Meier survival analysis, and natural splines were used.

resultsHealthy participants 66.23 ± 11.20 years and 62.71 ± 13.27 HCC patients showed no significant difference in their gender, age, highest education level, and the distribution of PBB counts. There was a significant difference in their TL. A significant correlation between PBB count and recurrence in HCC patients was observed. Significant spline terms (PBB count: p < 0.01; BAS TL: p < 0.001) confirmed nonlinear associations, justifying avoiding dichotomy. Patients with higher PBB counts (>0.125⋅10

conclusionThe preliminary results of this study support the use of PBB counting and TL for predicting HCC recurrence, supporting reliable nonlinear modeling.

Indexed as

BasophilHepatocellular carcinomaRecurrence.TelomeraseTelomere length

Identifiers

PMID41854795
PMCPMC13121665

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