ReviewArchives of virology2026
Viral subversion of neddylation: dual roles in replication efficiency and evasion of antiviral immunity.
Review in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Neddylation, a conserved ubiquitin-like modification, critically regulates viral pathogenesis and host immunity. This review synthesizes recent advances demonstrating how viruses exploit host neddylation to enhance replication—either by direct neddylation of viral proteins or by subverting cullin-RING ligases (CRLs) to degrade antiviral restriction factors. Conversely, neddylation bolsters innate immunity by activating Interferon Regulatory Factor 7 (IRF7) nuclear translocation, potentiating cylic GMP-AMP synthase -Stimulator of Interferon Genes ༈cGAS-STING༉ signaling, and regulating inflammasome-dependent cytokine responses. The NEDD8 activating enzyme E1 subunit 1(NAE1) inhibitor MLN4924 exhibits broad antiviral activity against herpesviruses, influenza, Human Immunodeficiency Virus, and coronaviruses. Understanding neddylation’s dual roles - as a proviral facilitator and immune modulator - provides novel insights for antiviral strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.