Evidence map›Paper›PMID 41854613›Full record

Trial reportJAMA network open2026

Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.

Wei Ni, Heng Yang, Jiabin Su, Ya Peng, Dengliang Wang, Zhiqing Lin, Jun Sun, Xuelin Chen, Jiyue Wang, Yi Li and 33 more

Registry-linked trialAbstract readRandomized Controlled TrialEquivalence TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA network open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05401669 (Transradial Versus Transfemoral Access for Cerebral Angiography), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05401669 narecruitingnot on this map

Transradial Versus Transfemoral Access for Cerebral Angiography

TypeinterventionalSponsorHuashan HospitalRan2023 to 2024Enrolled748ConditionsCerebral AngiographyArmsTrans-radial access, Trans-femoral access
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Wei NiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Heng YangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Jiabin SuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Ya PengDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, China.
Dengliang WangDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Zhiqing LinDepartment of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Jun SunDepartment of Neurosurgery, Panvascular Disease Management Center, Wenzhou Central Hospital, Wenzhou, China.
Xuelin ChenDepartment of Neurosurgery, Affiliated Zhongshan Hospital of Fudan University, Qingpu Branch, Shanghai, China.
Jiyue WangDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
Yi LiDepartment of Neurosurgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiaxiong WangDepartment of Neurosurgery, Southern Central Hospital of Yunnan Province, Honghe, China.
Shu WanDepartment of Neurosurgery, Zhejiang Hospital, Hangzhou, China.
Xin YeDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Hangzhou, China.
Qingrong ZhangDepartment of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Donghai WangDepartment of Neurosurgery, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China.
Chao GaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Hanqiang JiangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xinjie GaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yingying ZhangDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Bing HanDepartment of Neurosurgery, The Second People's Hospital of Dongying, Dongying, China.
Jie CaoDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, China.
Xucheng ZhuDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, China.
Shengjun ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Yiyong ZengDepartment of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Fuxiang ChenDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yuanxiang LinDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Huajun BaDepartment of Neurosurgery, Panvascular Disease Management Center, Wenzhou Central Hospital, Wenzhou, China.
Xiaoxiang ChenDepartment of Neurosurgery, Panvascular Disease Management Center, Wenzhou Central Hospital, Wenzhou, China.
Xianglu LiuDepartment of Neurosurgery, Affiliated Zhongshan Hospital of Fudan University, Qingpu Branch, Shanghai, China.
Jiheng HaoDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
Zhaoliang SunDepartment of Neurosurgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mei LiDepartment of Neurosurgery, Southern Central Hospital of Yunnan Province, Honghe, China.
Ming WangDepartment of Neurosurgery, Zhejiang Hospital, Hangzhou, China.
Dajiang XieDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Hangzhou, China.
Zong ZhuangDepartment of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Lin ShiDepartment of Neurosurgery, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China.
Liang ZhouCaidya (formerly dMed Biopharmaceutical Co Ltd), Shanghai, China.
Hongyu TangCaidya (formerly dMed Biopharmaceutical Co Ltd), Shanghai, China.
Dan ChenCaidya (formerly dMed Biopharmaceutical Co Ltd), Shanghai, China.
Craig S AndersonInstitute for Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.
Dezhi KangDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yuxiang GuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
TRACE Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Transradial access (TRA) has emerged as a promising alternative to standard transfemoral access (TFA) for interventional cardiac procedures, but its application for examination of the cerebral circulation has not been tested in a clinical trial. Objective: To compare the efficacy and safety of TRA with TFA for diagnostic cerebral angiography. Design, Setting, and Participants: This investigator-initiated, multicenter, open-label, noninferiority randomized clinical trial with a blinded outcome assessment was conducted at 13 sites in China. Patients eligible for cerebral angiography were randomized between September 15, 2023, and November 4, 2024, with final follow-up performed on November 27, 2024. The primary analysis was performed in the intention-to-treat population; secondary analyses were performed in the per-protocol population. Interventions: Patients were randomly allocated to TRA (n = 431) or TFA (n = 430) for diagnostic cerebral angiography. Main Outcomes and Measures: The primary outcome was the success of diagnostic cerebral angiography. Secondary outcomes were success in achieving an accurate diagnosis, duration of angiography and fluoroscopy, time in bed, and patient-reported satisfaction on an 11-point visual analog scale for pain (ranging from 0 [none] to 10 [worst possible]) within 24 hours after the procedure. The noninferiority margin was an absolute difference of 5% in success of angiographic diagnosis and success of accurate diagnosis. Results: A total of 858 patients (median age, 58.4 [IQR, 52.0-67.0] years; 479 [55.8%] male) completed the trial. Success of diagnostic cerebral angiography in the TRA group was lower than that in the TFA group (392 of 431 [91.0%] vs 409 of 427 [95.8%]; difference, -4.8 percentage points [pp] [95% CI, -8.1 to -1.5 pp]; relative risk [RR], 0.95 [95% CI, 0.92-0.98]; P = .46 for noninferiority test). The success rate of accurate diagnosis was 78.9% in the TRA group vs 91.1% in the TFA group (difference, -12.2 pp [95% CI, -16.9 to -7.5 pp]; RR, 0.87 [95% CI, 0.82-0.92]; P = .99 for noninferiority test). Compared with the TFA group, the TRA group had longer median times for angiography (33.7 [IQR, 23.0-40.0] vs 38.7 [IQR, 26.0-47.0] minutes; P < .001) and fluoroscopy (10.6 [IQR, 5.6-12.9] vs 11.8 [IQR, 6.2-15.0] minutes; P = .02); the TRA group had significantly shorter median time in bed (188.4 [IQR, 3.0-180.0] vs 1079.0 [IQR, 842.0-1366.0] minutes; P < .001) and lower median pain scores (0.5 [IQR, 0.0-1.0] vs 0.7 [IQR, 0.0-1.0]; P < .001). Overall angiography complications were comparable between the groups (19 of 445 [4.3%] vs 25 of 413 [6.1%]; P = .28), but TRA had more radial artery puncture failures than TFA. Conclusions and Relevance: In this randomized clinical trial of patients undergoing diagnostic cerebral angiography, TRA was not shown to be noninferior to TFA with regard to the success rate of diagnostic cerebral angiography. Additional research, including superiority trials, is needed to clearly define the comparative benefits of TRA and TFA. Trial Registration: ClinicalTrials.gov Identifier: NCT05401669.

Indexed as

Catheterization, PeripheralCerebral AngiographyFemoral ArteryRadial ArteryAgedChinaFemaleHumansMaleMiddle Aged

Identifiers

PMID41854613
PMCPMC13003373

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.