Evidence map›Paper›PMID 41854534›Full record

ReviewEpilepsia2026

Women with epilepsy: Evidence-based counseling across the lifespan.

Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert-Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz

Abstract readReview
In one paragraph

Review in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Neurology of Menopause.Current neurology and neuroscience reports · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara TettenbornBellevue Medical Group, Swiss Brain Health Center, Center for Sports Neurology, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-2072-7923
Georgia RamantaniDepartment of Neuropediatrics, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-7931-2327
Dominique FlügelDepartment of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Verena GausEpilepsy Center Berlin-Brandenburg, Institute for Diagnostics of Epilepsy, Berlin, Germany.ORCID https://orcid.org/0000-0001-6003-936X
Susanne Schubert-BastDepartment of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe University Frankfurt, University Medicine Frankfurt, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0003-1545-7364
Elisabeth SellittoSwiss Epilepsy Center, Klinik Lengg, Zurich, Switzerland.ORCID https://orcid.org/0009-0004-7633-7299
Jennifer BauschAngelini Pharma Switzerland, Zug, Switzerland.ORCID https://orcid.org/0009-0004-8373-4276
Bettina SchmitzStroke Unit, Clinic for Neurology, Epilepsy Center, Vivantes-Humboldt Clinic, Berlin, Germany.ORCID https://orcid.org/0000-0002-7700-1584

Funding

Angelini PharmaAnna Mueller Grocholski-StiftungSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 208184Vontobel-Stiftung
6 · The paper itself

Abstract

Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex-specific aspects of epilepsy has increased, important gaps remain in their integration into routine care. This review synthesizes current evidence on epilepsy management across key life stages, including adolescence and transition to adult care, reproductive health, contraception, fertility and pregnancy, lactation, menopause, and bone health. It integrates recent literature with expert interpretation in alignment with contemporary clinical guidelines, with the aim of enhancing clinical applicability. Hormonal changes, bidirectional interactions between antiseizure medications (ASMs), and reproductive physiology as well as shifting psychosocial demands influence seizure patterns, treatment efficacy, and long-term health outcomes in WWE. Particular focus is placed on interactions between epilepsy, endocrine regulation, and ASM therapy, and on teratogenic and neurodevelopmental risks associated with specific ASMs. Effective care for WWE requires continuous, individualized counseling that adapts to changing priorities and risks over time. Structured transition processes, evidence-based counseling on contraception and pregnancy, therapeutic drug monitoring during pregnancy, and transparent communication regarding fetal risks of ASMs are essential components of high-quality care. Beyond the reproductive years, seizure changes during menopause and the cumulative impact of long-term ASM exposure, particularly on bone health, require surveillance and prevention. Despite advances in pregnancy registries and treatment recommendations, participation in registries is low, and evidence outside pregnancy remains limited. Awareness of sex-specific epilepsy issues continues to be insufficient among both WWE and health care professionals. Addressing these gaps will require improved education, coordinated multidisciplinary care, and expanded research efforts to support patient-centered, lifelong care for WWE.

Indexed as

CounselingEpilepsyAnticonvulsantsEvidence-Based MedicineFemaleHumansPregnancyAnticonvulsantsantiseizure medicationsbreastfeedingmenopausepregnancytransition

Identifiers

PMID41854534
PMCPMC13285251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.